Otolaryngology Unit, San Camillo Forlanini Hospital, 00152 Rome, Italy.
Otolaryngology Division, Azienda Ospedaliera Universitaria di Sassari, 07100 Sassari, Italy.
Medicina (Kaunas). 2024 Nov 4;60(11):1808. doi: 10.3390/medicina60111808.
Cancers of the nose, and especially the nose vestibule, represent a significant challenge for clinicians due to their rarity, the intricate nature of surrounding vital structures, the nonspecific early symptoms, and the etiological factors that are not completely understood. Emerging research suggests that alterations in the nasal microbiome, also known as microbial dysbiosis, may contribute to the pathogenesis of those malignancies through mechanisms involving chronic inflammation, immune modulation, and cellular changes. The aims of this paper are to review the current literature covering the nasal microbiome's role in carcinogenesis, particularly in the context of squamous cell carcinoma, and to explore how microbial dysbiosis might foster a pro-tumorigenic environment. It further discusses potential future directions for research and therapeutic approaches.
鼻腔，尤其是鼻前庭的癌症，因其罕见性、周围重要结构的复杂性、非特异性的早期症状以及不完全清楚的病因因素，给临床医生带来了巨大的挑战。新兴研究表明，鼻腔微生物组（也称为微生物失调）的改变可能通过涉及慢性炎症、免疫调节和细胞变化的机制，促进这些恶性肿瘤的发病机制。本文的目的是回顾当前涵盖鼻腔微生物组在致癌作用中的作用的文献，特别是在鳞状细胞癌的背景下，并探讨微生物失调如何促进促肿瘤环境。它进一步讨论了未来研究和治疗方法的潜在方向。
