Department of Nursing, University of Valencia, 46010 Valencia, Spain.
Department of Physiotherapy, University of Valencia, 46010 Valencia, Spain.
Medicina (Kaunas). 2024 Nov 18;60(11):1893. doi: 10.3390/medicina60111893.
: Adjuvant treatment with aromatase inhibitors (AIs) in breast cancer (BC) survivors can cause adverse effects such as metabolic syndrome (MS) (insulin resistance, central obesity, atherogenic dyslipidemia, and hypertension) associated with morbidity and premature mortality. We evaluate the effect of a multimodal program based on physical exercise and health education on MS and health-related quality of life (QoL) in postmenopausal women with BC under AIs. : A total of 56 postmenopausal women, diagnosed with BC, aged 60 years or older (mean age 67.2 years) and on hormonal treatment with AIs, were included in the multimodal physical exercise and health education program, and evaluated before and after their participation. The assessment of the five criteria of the MS included the following: waist circumference, high blood pressure, fasting glucose, triglycerides, and high-density lipoprotein cholesterol. Two main instruments were used to evaluate the impact of the intervention on QoL: the EORTC QLQ C30 (questionnaire for cancers in general) and the EORTC QLQ BR23 (specifically for breast cancer patients). The EuroQol 5D (EQ-5D) was also used to compare these results. : The percentage of women meeting the MS criteria was 37.7% at baseline and fell to 15.1% at 3 months after the intervention ( = 0.02). The intervention significantly reduced hypertension ( < 0.001), central obesity ( < 0.001), and the concentration of triglycerides ( = 0.016). No significant changes were observed in fasting glucose and HDL concentration. A statistically significant improvement was found in QoL (on both the QLQ30 and BR23 scales). A multivariate regression model analysis identified marital status (being married) (95% CI: 1.728-131.615, = 0.014), and percentage of attendance at health education sessions (95% CI: 1.010-1.211, = 0.029) as positive predictive variables of improvement in MS. : The implementation of multimodal, community-based programs of physical exercise and health education improve the prevalence of MS and specific criteria of MS and QoL in postmenopausal women with breast cancer receiving AI treatment.
辅助治疗乳腺癌（BC）幸存者中的芳香酶抑制剂（AIs）可能会导致代谢综合征（MS）（胰岛素抵抗、中心性肥胖、动脉粥样硬化性血脂异常和高血压）等不良影响，这些不良影响与发病率和过早死亡率有关。我们评估了基于体育锻炼和健康教育的多模式方案对接受 AI 治疗的绝经后 BC 妇女中 MS 和健康相关生活质量（QoL）的影响。
共纳入 56 名绝经后 BC 妇女，年龄 60 岁或以上（平均年龄 67.2 岁），正在接受激素治疗 AI，参与多模式体育锻炼和健康教育计划，并在参与前后进行评估。MS 的五个标准的评估包括腰围、高血压、空腹血糖、甘油三酯和高密度脂蛋白胆固醇。使用两种主要仪器评估干预对 QoL 的影响：EORTC QLQ C30（一般癌症问卷）和 EORTC QLQ BR23（专门用于乳腺癌患者）。还使用 EuroQol 5D（EQ-5D）进行比较。
基线时，符合 MS 标准的女性百分比为 37.7%，干预 3 个月后降至 15.1%（ = 0.02）。干预显著降低了高血压（<0.001）、中心性肥胖（<0.001）和甘油三酯浓度（=0.016）。空腹血糖和 HDL 浓度无明显变化。QLQ30 和 BR23 量表的 QoL 均有显著改善。多变量回归模型分析确定婚姻状况（已婚）（95%CI：1.728-131.615，=0.014）和健康教育课程出勤率百分比（95%CI：1.010-1.211，=0.029）是 MS 改善的正预测变量。
实施基于社区的多模式体育锻炼和健康教育方案可改善接受 AI 治疗的绝经后 BC 妇女的 MS 患病率和特定 MS 及 QoL 标准。
