Department of Psychiatric Internal Medicine, Sunlight Brain Research Center, Hofu 7470066, Japan.
Department of Psychosomatic Dentistry, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Bunkyou 1138510, Japan.
Medicina (Kaunas). 2024 Nov 19;60(11):1895. doi: 10.3390/medicina60111895.
Irritable bowel syndrome (IBS) represents the most prevalent disorder of brain-gut interaction, affecting approximately 10% of the global population. The objective of this study was to examine the mechanisms by which the gut microbiota contributes to the development of IBS. To this end, a review of articles that examined the gut microbiota of IBS patients was conducted. A search was conducted using PubMed and J-STAGE for articles published over the past five years that relate to the gut microbiota in patients with IBS. Individuals diagnosed with IBS display a reduction in alpha diversity and a decline in butyrate-producing bacteria, which collectively indicate a state of dysbiosis within their gut microbiota. Butyrate plays a dual role in the body, acting as a source of nutrition for the intestinal epithelium while also regulating the expression of dopamine transporters and D2 receptors in the central nervous system through epigenetic mechanisms. These characteristics may be linked to dysfunction of the central dopamine D2 pathway and play a role in the formation of various symptoms in IBS.
肠易激综合征（IBS）代表了最常见的脑-肠相互作用紊乱，影响了全球约 10%的人口。本研究旨在探讨肠道微生物群如何促进 IBS 的发展。为此，对检查 IBS 患者肠道微生物群的文章进行了综述。使用 PubMed 和 J-STAGE 对过去五年内与 IBS 患者肠道微生物群相关的文章进行了检索。被诊断患有 IBS 的个体表现出 alpha 多样性减少和产生丁酸盐的细菌减少，这共同表明其肠道微生物群处于生态失调状态。丁酸盐在体内具有双重作用，既是肠道上皮细胞的营养来源，又通过表观遗传机制调节中枢神经系统中多巴胺转运体和 D2 受体的表达。这些特征可能与中枢多巴胺 D2 途径的功能障碍有关，并在 IBS 的各种症状形成中发挥作用。
