Ben Abdeladhim Rim, Reis José Alexandre, Vieira Ana Maria, de Almeida Catarina Dias
Egas Moniz School of Health & Science, Campus Universitário, Quinta da Granja, 2829-511 Caparica, Portugal.
Egas Moniz Center for Interdisciplinary Research (CiiEM), Egas Moniz School of Health & Science, Campus Universitário, Quinta da Granja, 2829-511 Caparica, Portugal.
Materials (Basel). 2024 Nov 6;17(22):5415. doi: 10.3390/ma17225415.
Polyhydroxyalkanoates (PHAs) are promising biopolymers as an alternative to traditional synthetic polymers due to their biodegradability and biocompatibility. The PHA market is blooming in response to the growing demand for biodegradable and environmentally friendly plastics. These biopolyesters are produced and degraded by a variety of microorganisms, making them environmentally friendly, while offering benefits such as biocompatibility (when adequately processed) and biodegradability. Their versatility extends to various areas, from biomedicine to agriculture and composite materials, where they pave the way for significative innovations. In the field of regenerative medicine, some PHAs have key applications, namely in vascular grafts, oral tissue regeneration, and development of self-healing polymers. In addition, PHAs have the potential to be used in the creation of dental implant materials and dental medical devices. PHAs can also be used to encapsulate hydrophobic drugs, providing an approach for more targeted and effective treatments. To summarize, PHAs open new perspectives in the field of medicine by improving drug delivery and offering ecologically biocompatible solutions for medical devices. The aim of this review is to present the medical and dental applications of PHA, their advantages, disadvantages, and indications.
聚羟基脂肪酸酯（PHA）作为传统合成聚合物的替代品，因其生物可降解性和生物相容性而成为有前景的生物聚合物。随着对可生物降解和环保塑料需求的不断增长，PHA市场正在蓬勃发展。这些生物聚酯由多种微生物产生和降解，使其具有环境友好性，同时还具有生物相容性（经过适当加工时）和生物可降解性等优点。它们的多功能性延伸到各个领域，从生物医学到农业和复合材料，为重大创新铺平了道路。在再生医学领域，一些PHA具有关键应用，即在血管移植物、口腔组织再生和自愈聚合物的开发中。此外，PHA有潜力用于制造牙科植入材料和牙科医疗设备。PHA还可用于封装疏水性药物，提供一种更具针对性和有效性的治疗方法。总之，PHA通过改善药物递送并为医疗设备提供生态生物相容性解决方案，在医学领域开辟了新的前景。本综述的目的是介绍PHA在医学和牙科方面的应用、它们的优点、缺点和适应症。
