Kashyap Bina, Padala Sridhar Reddy, Kaur Gaganjot, Kullaa Arja
Institute of Dentistry, University of Eastern Finland, 70211 Kuopio, Finland.
Agartala Government Dental College, West Tripura, Agartala 799001, India.
Microorganisms. 2024 Oct 24;12(11):2138. doi: 10.3390/microorganisms12112138.
are ubiquitous fungal organisms that colonize the oral cavity of healthy individuals without causing disease. is an opportunistic microorganism with several virulent factors that influence the inflammatory process and allow it to invade tissues, evade host defense mechanisms, and release toxins, facilitating proliferation and degradation. At present, increasing emphasis is placed on polymicrobial interactions between and various bacterial pathogens. Such interaction is mutually beneficial for both parties: it is competitive and antagonistic. Their complex interaction and colonization in the oral cavity serve as the basis for several oral diseases. The dispersion of in saliva and the systemic circulation is noted in association with other bacterial populations, suggesting their virulence in causing disease. Hence, it is necessary to understand fungal-bacterial interactions for early detection and the development of novel therapeutic strategies to treat oral diseases. In this paper, we review the mutualistic interaction of in oral biofilm formation and polymicrobial interactions in oral diseases. In addition, virulence in causing biofilm-related oral diseases and its presence in saliva are discussed.
是普遍存在的真菌生物体，可定殖于健康个体的口腔而不引起疾病。是一种具有多种毒力因子的机会性微生物，这些毒力因子会影响炎症过程，并使其能够侵入组织、逃避宿主防御机制并释放毒素，从而促进增殖和降解。目前，人们越来越重视与各种细菌病原体之间的多微生物相互作用。这种相互作用对双方都互利：它具有竞争性和拮抗性。它们在口腔中的复杂相互作用和定殖是多种口腔疾病的基础。与其他细菌群体相关的情况下，在唾液和全身循环中的扩散被注意到，这表明它们在致病方面的毒力。因此，有必要了解真菌与细菌的相互作用，以便早期检测和开发治疗口腔疾病的新型治疗策略。在本文中，我们综述了在口腔生物膜形成中的共生相互作用以及口腔疾病中的多微生物相互作用。此外，还讨论了在引起生物膜相关口腔疾病中的毒力及其在唾液中的存在情况。
