Schnur P, Raigoza V R
Life Sci. 1986 Apr 7;38(14):1323-9. doi: 10.1016/0024-3205(86)90427-3.
Two experiments investigated the effects of naloxone on morphine elicited hyperactivity in the hamster. In Experiment 1, naloxone (0.4 mg/kg) administered two hours after morphine (15 mg/kg) produced sedation in animals running at high rates under the influence of morphine. Saline control animals running at comparable rates were unaffected by naloxone. In Experiment 2, naloxone administered two hours after morphine converted morphine elicited hyperactivity into sedation. These results are discussed in terms of a modified dual-action hypothesis which holds that morphine elicited hyperactivity masks an underlying opponent process.
两项实验研究了纳洛酮对吗啡引起的仓鼠多动的影响。在实验1中，在注射吗啡（15毫克/千克）两小时后注射纳洛酮（0.4毫克/千克），导致在吗啡影响下高速奔跑的动物出现镇静作用。以类似速度奔跑的生理盐水对照动物不受纳洛酮影响。在实验2中，在注射吗啡两小时后注射纳洛酮，将吗啡引起的多动转变为镇静。这些结果根据一种修正的双作用假说来讨论，该假说认为吗啡引起的多动掩盖了一个潜在的对抗过程。
