从天然发酵牦牛酸奶中分离得到的HFY11对盐酸林可霉素诱导的小鼠腹泻的治疗作用

Therapeutic Effect of HFY11 Isolated from Naturally Fermented Yak Yogurt on Lincomycin Hydrochloride-Induced Diarrhea in Mice.

作者信息

Tan Fang, Ren Lixuan, Kong Chang-Suk

机构信息

Department of Bioscience, Silla University, Busan 46958, Republic of Korea.

Department of Food Science and Nutrition, Silla University, Busan 46958, Republic of Korea.

出版信息

Microorganisms. 2024 Nov 13;12(11):2307. doi: 10.3390/microorganisms12112307.

DOI:10.3390/microorganisms12112307

PMID:39597698

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11596483/

Abstract

This study aimed to observe the therapeutic effect of HFY11 (LP-HFY11) on lincomycin hydrochloride-induced diarrhea in mice. The results showed that LP-HFY11 alleviated weight loss and intestinal and colon tissue lesions caused by diarrhea. The serum assay showed that LP-HFY11 decreased interleukin 17A (IL-17A), IL-6, 5-hydroxytryptamine, and malondialdehyde levels and increased total antioxidant capacity in mice with diarrhea. LP-HFY11 also downregulated the mRNA expression of cystic fibrosis transmembrane conductance regulator (CFTR), epidermal growth factor receptor (EGFR), and transforming growth factor beta 1 (TGFβ1) and upregulated the expression of recombinant sodium/hydrogen exchanger 1 (NHE1) and NHE4 in the colon tissues of mice with diarrhea. In conclusion, the study showed that LP-HFY11 could effectively inhibit diarrhea, and the effect was better than that of the drug tetragenous viable bacteria tablets (-TVBT).

摘要

本研究旨在观察HFY11（LP-HFY11）对盐酸林可霉素诱导的小鼠腹泻的治疗效果。结果表明，LP-HFY11减轻了腹泻引起的体重减轻以及肠道和结肠组织损伤。血清检测显示，LP-HFY11降低了腹泻小鼠的白细胞介素17A（IL-17A）、IL-6、5-羟色胺和丙二醛水平，并提高了总抗氧化能力。LP-HFY11还下调了腹泻小鼠结肠组织中囊性纤维化跨膜传导调节因子（CFTR）、表皮生长因子受体（EGFR）和转化生长因子β1（TGFβ1）的mRNA表达，并上调了重组钠/氢交换体1（NHE1）和NHE4的表达。总之，该研究表明LP-HFY11可有效抑制腹泻，且效果优于药物四联活菌片（-TVBT）。