Bonilla Marco, Martín-Morales Natividad, Gálvez-Rueda Rocío, Raya-Álvarez Enrique, Mesa Francisco
Higher Technician in Clinical and Biomedical Laboratory, Centro de Investigación Biomédica (CIBM), 18016 Granada, Spain.
Department of Pathology, School of Medicine, University of Granada, 18016 Granada, Spain.
J Clin Med. 2024 Nov 13;13(22):6831. doi: 10.3390/jcm13226831.
: This review synthesizes the role of () and () in modulating immune responses through citrullination and assesses its impact on periodontitis and systemic conditions. A systematic review was conducted on preclinical and clinical studies focusing on and -induced citrullination and its effects on immune responses, particularly inflammatory pathways, and systemic diseases. The search included PubMed, Scopus, Google Scholar, Web of Science, and gray literature. Quality and risk of bias were assessed using OHAT Rob Toll and QUIN-Tool. The review is registered in PROSPERO (ID: CRD42024579352). 18 articles published up to August 2024 were included. Findings show that and citrullination modulates immune responses, leading to neutrophil dysfunction and chronic inflammation. Key mechanisms include citrullination of antimicrobial peptides, CXCL10, histone H3, α-enolase, and C5a, impairing neutrophil activation and promoting NET formation. This review suggests that and citrullination modulates immune responses and may influence periodontitis and systemic conditions like RA. Beyond ACPA production, these pathogens affect key proteins such as H3, C5a, and CXCL10, as well as antimicrobial peptides, NET formation, and phagocytosis. These interactions lead to neutrophil dysfunction and potentially affect other cells, subsequently disrupting local and systemic inflammatory responses.
本综述综合了（）和（）通过瓜氨酸化调节免疫反应的作用，并评估其对牙周炎和全身状况的影响。对侧重于（）和（）诱导的瓜氨酸化及其对免疫反应，特别是炎症途径和全身疾病影响的临床前和临床研究进行了系统综述。检索范围包括PubMed、Scopus、谷歌学术、科学网和灰色文献。使用OHAT Rob Toll和QUIN-Tool评估质量和偏倚风险。该综述已在PROSPERO注册（ID：CRD42024579352）。纳入了截至2024年8月发表的18篇文章。研究结果表明，（）和（）瓜氨酸化调节免疫反应，导致中性粒细胞功能障碍和慢性炎症。关键机制包括抗菌肽、CXCL10、组蛋白H3、α-烯醇化酶和C5a的瓜氨酸化，损害中性粒细胞活化并促进中性粒细胞胞外陷阱形成。本综述表明，（）和（）瓜氨酸化调节免疫反应，并可能影响牙周炎和类风湿关节炎等全身状况。除了抗环瓜氨酸肽的产生外，这些病原体还影响关键蛋白，如H3、C5a和CXCL10，以及抗菌肽、中性粒细胞胞外陷阱形成和吞噬作用。这些相互作用导致中性粒细胞功能障碍，并可能影响其他细胞，随后破坏局部和全身炎症反应。
