Borrelli Nunzia, Merola Assunta, Barracano Rosaria, Palma Michela, Altobelli Ippolita, Abbate Massimiliana, Papaccioli Giovanni, Ciriello Giovanni Domenico, Liguori Carmen, Sorice Davide, De Luca Lorenzo, Scognamiglio Giancarlo, Sarubbi Berardo
Adult Congenital Heart Disease and Familiar Arrhythmias Unit, Monaldi Hospital, 80131 Naples, Italy.
J Clin Med. 2024 Nov 14;13(22):6839. doi: 10.3390/jcm13226839.
Advances in medical and surgical interventions have resulted in a steady increase in the number of patients with congenital heart disease (CHD) reaching adult age. Unfortunately, this ever-growing population faces an added challenge: an increased risk of acquiring coronary artery disease. This review provides insight into the complex interactions between coronary artery disease and CHD in adults. We describe the peculiar features of cardiac anatomy in these patients, the possible role cardiac sequelae may play in an increased risk of myocardial ischemia, and the diagnostic challenges in this patient group. Furthermore, this review outlines the risk factors and potential mechanisms of accelerated atherosclerosis in adults with CHD by pointing out areas where current knowledge is incomplete and highlighting areas for further research. The review concludes by examining potential management strategies for this particular population, emphasizing the necessity for a multidisciplinary approach. Understanding the unique coronary risks that adults with CHD experience can enhance patient care and improve long-term results.
医学和外科干预措施的进步使得先天性心脏病（CHD）患者活到成年的人数稳步增加。不幸的是，这一不断增长的群体面临着额外的挑战：患冠状动脉疾病的风险增加。本综述深入探讨了成人冠状动脉疾病与CHD之间的复杂相互作用。我们描述了这些患者心脏解剖结构的特殊特征、心脏后遗症可能在增加心肌缺血风险中所起的作用，以及该患者群体的诊断挑战。此外，本综述通过指出当前知识不完整的领域并强调进一步研究的领域，概述了成人CHD患者加速动脉粥样硬化的风险因素和潜在机制。综述最后审视了针对这一特定人群的潜在管理策略，强调了多学科方法的必要性。了解成人CHD患者所面临的独特冠状动脉风险可以加强患者护理并改善长期治疗效果。
