Alcázar-Hernández Juan Manuel, Pecci-Lloret Miguel Ramón, Guerrero-Gironés Julia
Gerodontologý an Special Care Dentistry Unit, Morales Meseguer Hospital, Faculty of Medicine, University of Murcia, 30008 Murcia, Spain.
J Clin Med. 2024 Nov 18;13(22):6945. doi: 10.3390/jcm13226945.
: The rising use of antidepressants is linked to oral health risks, including xerostomia, caries, and periodontal disease. Recognizing these risks is essential for improving patient care. To systematically review oral manifestations in patients undergoing antidepressant treatment. : This review follows the PRISMA guidelines and includes observational studies published in the last 21 years. A PICO-based question was developed to select relevant studies, which were assessed for quality using a modified STROBE checklist. : A total of 11 studies were analyzed, revealing a consistent association between antidepressant use and the increased risk of xerostomia, caries, and periodontal disease. Additional findings included taste dysfunction and oral bleeding complications. Among the antidepressants, selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs) were most commonly associated with xerostomia and caries. However, no significant impact was observed on the chemical composition of saliva or on hemostasis in invasive dental procedures. : Antidepressant use may lead to significant oral health issues, notably xerostomia and caries. Further studies are recommended to clarify the influence of specific antidepressants and confounding factors, such as treatment duration, dosage, and hygiene habits, on oral health outcomes.
抗抑郁药使用的增加与口腔健康风险相关，包括口干、龋齿和牙周疾病。认识到这些风险对于改善患者护理至关重要。旨在系统回顾接受抗抑郁药治疗患者的口腔表现。
本综述遵循PRISMA指南，纳入过去21年发表的观察性研究。制定了基于PICO的问题以选择相关研究，并使用改良的STROBE清单评估研究质量。
共分析了11项研究，结果显示抗抑郁药的使用与口干、龋齿和牙周疾病风险增加之间存在一致关联。其他发现包括味觉功能障碍和口腔出血并发症。在抗抑郁药中，选择性5-羟色胺再摄取抑制剂（SSRIs）和三环类抗抑郁药（TCAs）与口干和龋齿最为相关。然而，未观察到对唾液化学成分或侵入性牙科手术中的止血有显著影响。
使用抗抑郁药可能导致严重的口腔健康问题，尤其是口干和龋齿。建议进一步研究以阐明特定抗抑郁药和混杂因素（如治疗持续时间、剂量和卫生习惯）对口腔健康结果的影响。
