Nurzyńska-Wierdak Renata
Department of Vegetable and Herb Crops, Faculty of Horticulture and Landscape Architecture, University of Life Sciences in Lublin, Doświadczalna 50a, 20-280 Lublin, Poland.
Pharmaceuticals (Basel). 2024 Nov 6;17(11):1489. doi: 10.3390/ph17111489.
Depression is one of the most common diseases in the world, and it is also the most common mental disorder. Depressive disorders are a real threat not only to individuals, but also to the general population. This disease is a leading cause of disability and inability to work. Due to the numerous side effects of conventional drugs, attention is increasingly being paid to other solutions, including herbal medicines. Many plant species are known for their traditional uses in the treatment of anxiety, insomnia, and depression. The clinically proven effects of adaptogenic raw materials on depression symptoms are probably related to the positive impact of some secondary metabolites (terpenoids, alkaloids, glucosinolates, phenols). Currently, it is emphasized that in many cases the antioxidant and anti-inflammatory properties of plant substances play a protective role at the neurocellular level. Among the medicinal plants analyzed in clinical trials for the treatment of depression, the following seem to be particularly interesting: saffron (Crocus L.), turmeric (Curcuma L.), ginkgo (Ginkgo L.), St. John's wort (Hypericum L.), and passionflower (Passiflora L.), which have broad and strong biological activity, well-documented history of action and use, and effectiveness in preventing and/or treating anxiety and depression. These plants are still in the sphere of biochemical and phytopharmaceutical research, the results of which are very promising.
抑郁症是世界上最常见的疾病之一，也是最常见的精神障碍。抑郁症不仅对个人，而且对普通人群都是一种真正的威胁。这种疾病是导致残疾和无法工作的主要原因。由于传统药物有众多副作用，人们越来越关注其他解决方案，包括草药。许多植物物种因其在治疗焦虑、失眠和抑郁症方面的传统用途而闻名。适应原性原料对抑郁症状的临床验证效果可能与某些次生代谢产物（萜类化合物、生物碱、硫代葡萄糖苷、酚类）的积极影响有关。目前，人们强调在许多情况下，植物物质的抗氧化和抗炎特性在神经细胞水平上发挥着保护作用。在治疗抑郁症的临床试验中分析的药用植物中，以下几种似乎特别有趣：藏红花（番红花属）、姜黄（姜黄属）、银杏（银杏属）、圣约翰草（金丝桃属）和西番莲（西番莲属），它们具有广泛而强大的生物活性、有充分文献记载的作用和使用历史，以及在预防和/或治疗焦虑和抑郁症方面的有效性。这些植物仍处于生化和植物药学研究领域，其结果非常有前景。
