Key Laboratory of National Forestry and Grassland Administration on Cultivation of Fast-Growing Timber in Central South China, College of Forestry, Guangxi University, Nanning 540004, China.
Molecules. 2023 Mar 24;28(7):2922. doi: 10.3390/molecules28072922.
Continuous innovation in artificially-induced agarwood technology is increasing the amount of agarwood and substantially alleviating shortages. Agarwood is widely utilized in perfumes and fragrances; however, it is unclear whether the overall pharmacological activity of induced agarwood can replace wild agarwood for medicinal use. In this study, the volatile components, total chromone content, and the differences in the overall activities of wild agarwood and induced agarwood, including the antioxidant, anti-acetylcholinesterase, and anti-glucosidase activity were all determined. The results indicated that both induced and wild agarwood's chemical makeup contains sesquiterpenes and 2-(2-phenylethyl)chromones. The total chromone content in generated agarwood can reach 82.96% of that in wild agarwood. Induced agarwood scavenged 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radicals and inhibited acetylcholinesterase activity and α-glucosidase activity with IC values of 0.1873 mg/mL, 0.0602 mg/mL, 0.0493 mg/mL, and 0.2119 mg/mL, respectively, reaching 80.89%, 93.52%, 93.52%, and 69.47% of that of wild agarwood, respectively. Accordingly, the results distinguished that induced agarwood has the potential to replace wild agarwood in future for use in medicine because it has a similar chemical makeup to wild agarwood and has comparable antioxidant, anti-acetylcholinesterase, and anti-glucosidase capabilities.
人工沉香技术的持续创新正在增加沉香的产量，并在很大程度上缓解了短缺问题。沉香广泛应用于香水和香料中；然而，目前尚不清楚人工沉香的整体药理活性是否可以替代野生沉香用于药用。在这项研究中，测定了野生沉香和人工沉香的挥发性成分、总色酮含量以及整体活性的差异，包括抗氧化、抗乙酰胆碱酯酶和抗葡萄糖苷酶活性。结果表明，人工沉香和野生沉香的化学成分均含有倍半萜和 2-(2-苯乙基)色酮。人工沉香中总色酮的含量可达到野生沉香的 82.96%。人工沉香清除 1,1-二苯基-2-苦基肼 (DPPH) 自由基和 2,2'-联氮-双(3-乙基苯并噻唑啉-6-磺酸) (ABTS) 自由基，抑制乙酰胆碱酯酶和α-葡萄糖苷酶活性，IC 值分别为 0.1873 mg/mL、0.0602 mg/mL、0.0493 mg/mL 和 0.2119 mg/mL，分别达到野生沉香的 80.89%、93.52%、93.52%和 69.47%。因此，结果表明，人工沉香具有在未来替代野生沉香用于医学的潜力，因为它具有与野生沉香相似的化学成分，并且具有相当的抗氧化、抗乙酰胆碱酯酶和抗葡萄糖苷酶能力。
