Institute of Modern Fermentation Engineering and Future Foods, School of Light Industry and Food Engineering, Guangxi University, No. 100, Daxuedong Road, Nanning 530004, China.
School of Pharmaceutical Sciences and Institute of Materia Medica, Xinjiang University, Urumqi 830017, China.
Molecules. 2024 Nov 11;29(22):5315. doi: 10.3390/molecules29225315.
The gene is one of the genes most closely associated with human tumors and has become a popular target for tumor drug design. Currently, -based gene therapy techniques have been developed, but these therapies face challenges such as immaturity, high safety hazards, limited efficacy, and low patient acceptance. However, researchers are no less enthusiastic about the treatment because of its theoretical potential to treat cancer. In this paper, the advances in -based gene therapy and related nucleic acid delivery technologies were reviewed and prospected in order to support further development in this field.
该基因是与人类肿瘤关系最密切的基因之一，已成为肿瘤药物设计的热门靶点。目前，已经开发了基于的基因治疗技术，但这些疗法面临不成熟、安全性高、疗效有限和患者接受度低等挑战。然而，由于其治疗癌症的理论潜力，研究人员对这种治疗方法的热情并未减少。本文综述了基于的基因治疗及相关核酸传递技术的研究进展，并对其进行了展望，以期为该领域的进一步发展提供支持。
