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pH 响应型金属有机框架用于杀菌剂的靶向递送、释放行为和可持续植物保护。

pH-Responsive Metal-Organic Framework for Targeted Delivery of Fungicide, Release Behavior, and Sustainable Plant Protection.

机构信息

College of Plant Protection, Shanxi Agricultural University, Jinzhong 030801, China.

出版信息

Molecules. 2024 Nov 12;29(22):5330. doi: 10.3390/molecules29225330.

DOI:10.3390/molecules29225330
PMID:39598719
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11596698/
Abstract

A smart and environmentally friendly pesticide system was developed that could respond to environmental stimuli while mitigating environmental risks. In this study, thiabendazole (Thi), an effective fungicide, was loaded onto zeolitic imidazolate framework-8 (ZIF-8) using the impregnation method to fabricate a pH-responsive nano hybrid delivery system (Thi@ZIF-8). The results demonstrated that Thi@ZIF-8 had a rhombic dodecahedral morphology and a loading capacity of approximately 25%. Notably, the amount of Thi released from Thi@ZIF-8 at a pH of 5.0 reached 79.54%, which was higher than that at pH 7.0 and 9.0, for 251 h. Such pH-responsive release characteristics of Thi@ZIF-8 were probably related to the pH-dependent structure stability of ZIF-8. The release mechanism of Thi@ZIF-8 conformed to non-Fickian diffusion. Additionally, Thi@ZIF-8 showed a higher control efficacy against compared with Thi alone. Importantly, the ZIF-8 carrier could effectively reduce the leaching loss of Thi in soil and showed no negative effects on the three varieties of tomato seedlings, implying good biocompatibility. This work provides a novel and eco-friendly approach to control B. cinerea effectively that has great potential in modern sustainable agriculture.

摘要

研制了一种智能环保型农药系统，该系统能够响应环境刺激，同时降低环境风险。本研究采用浸渍法将有效杀菌剂噻菌灵（Thi）负载到沸石咪唑酯骨架-8（ZIF-8）上，制备了一种 pH 响应的纳米杂化递药系统（Thi@ZIF-8）。结果表明，Thi@ZIF-8 具有菱十二面体形态，载药量约为 25%。值得注意的是，在 pH 5.0 时，Thi@ZIF-8 中释放的 Thi 量达到 79.54%，高于在 pH 7.0 和 9.0 时的 251 h 时的释放量。Thi@ZIF-8 的这种 pH 响应释放特性可能与 ZIF-8 的 pH 依赖性结构稳定性有关。Thi@ZIF-8 的释放机制符合非 Fickian 扩散。此外，与单独使用 Thi 相比，Thi@ZIF-8 对 B. cinerea 的防治效果更高。重要的是，ZIF-8 载体可以有效减少 Thi 在土壤中的浸出损失，对三种番茄幼苗没有负面影响，表明其具有良好的生物相容性。这项工作为有效防治 B. cinerea 提供了一种新颖且环保的方法，在现代可持续农业中有很大的应用潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e35c/11596698/b64ddc4d4f35/molecules-29-05330-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e35c/11596698/31bc06c466aa/molecules-29-05330-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e35c/11596698/36db5e38f90e/molecules-29-05330-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e35c/11596698/99d6f67d9218/molecules-29-05330-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e35c/11596698/275125450773/molecules-29-05330-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e35c/11596698/e9cd0a949b89/molecules-29-05330-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e35c/11596698/6578fdc13fdd/molecules-29-05330-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e35c/11596698/07e81dd6a3f3/molecules-29-05330-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e35c/11596698/1203b6fd81f1/molecules-29-05330-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e35c/11596698/b64ddc4d4f35/molecules-29-05330-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e35c/11596698/31bc06c466aa/molecules-29-05330-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e35c/11596698/047962afa900/molecules-29-05330-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e35c/11596698/d5925101eaf3/molecules-29-05330-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e35c/11596698/147ede78fa2b/molecules-29-05330-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e35c/11596698/36db5e38f90e/molecules-29-05330-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e35c/11596698/99d6f67d9218/molecules-29-05330-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e35c/11596698/275125450773/molecules-29-05330-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e35c/11596698/e9cd0a949b89/molecules-29-05330-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e35c/11596698/6578fdc13fdd/molecules-29-05330-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e35c/11596698/07e81dd6a3f3/molecules-29-05330-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e35c/11596698/1203b6fd81f1/molecules-29-05330-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e35c/11596698/b64ddc4d4f35/molecules-29-05330-g012.jpg

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