Genus Stachys-Phytochemistry, Traditional Medicinal Uses, and Future Perspectives.

The genus represents one of the most extensive genera within the subfamily and ranks as one of the largest genera in the family. Many species are associated with a rich history in traditional medicine across various cultures, and their extracts and essential oils are rich in non-volatile and volatile compounds. Because of their complex profile of bioactive substances, members are considered to possess an extensive spectrum of therapeutic properties, including antioxidant, anti-inflammatory, analgesic, antibacterial, cytotoxic, and wound-healing effects, as well as benefits for memory enhancement, lipid profile regulation, blood glucose control, and weight management. Despite the wide distribution and chemical diversity of the genus, studies on its biological activities remain limited. The aim of this review is to summarize the most relevant data from studies on the bioactive compounds, traditional uses, and pharmacological properties of species found in databases such as Science Direct, PubMed, and Scopus. Specific keywords were used in the search strategy, including "bioactive compounds", "Stachys", "Lamiaceae", "Stachys extract", "Stachys essential oil", "traditional uses", "chemical composition", "therapeutic potential", "clinical trials", "in vivo studies", "in vitro studies". The search strategy was performed according to the guidelines for Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Data from 171 studies were included. The manuscript highlights the drug-discovery potential of species, emphasizing their potential applications in medicine, cosmetics, dietary supplements, and the food industry. Moreover, it provides important data that could assist Stachys research programs.