Department of Pharmacognosy and Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University of Plovdiv, 4002 Plovdiv, Bulgaria.
Research Institute, Medical University of Plovdiv, 4002 Plovdiv, Bulgaria.
Molecules. 2024 Nov 13;29(22):5345. doi: 10.3390/molecules29225345.
The genus represents one of the most extensive genera within the subfamily and ranks as one of the largest genera in the family. Many species are associated with a rich history in traditional medicine across various cultures, and their extracts and essential oils are rich in non-volatile and volatile compounds. Because of their complex profile of bioactive substances, members are considered to possess an extensive spectrum of therapeutic properties, including antioxidant, anti-inflammatory, analgesic, antibacterial, cytotoxic, and wound-healing effects, as well as benefits for memory enhancement, lipid profile regulation, blood glucose control, and weight management. Despite the wide distribution and chemical diversity of the genus, studies on its biological activities remain limited. The aim of this review is to summarize the most relevant data from studies on the bioactive compounds, traditional uses, and pharmacological properties of species found in databases such as Science Direct, PubMed, and Scopus. Specific keywords were used in the search strategy, including "bioactive compounds", "Stachys", "Lamiaceae", "Stachys extract", "Stachys essential oil", "traditional uses", "chemical composition", "therapeutic potential", "clinical trials", "in vivo studies", "in vitro studies". The search strategy was performed according to the guidelines for Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Data from 171 studies were included. The manuscript highlights the drug-discovery potential of species, emphasizing their potential applications in medicine, cosmetics, dietary supplements, and the food industry. Moreover, it provides important data that could assist Stachys research programs.
该属是唇形科 下的最广泛的属之一，也是 科中最大的属之一。许多 物种在各种文化的传统医学中都有着悠久的历史，其提取物和精油富含非挥发性和挥发性化合物。由于其生物活性物质的复杂特性， 成员被认为具有广泛的治疗特性，包括抗氧化、抗炎、镇痛、抗菌、细胞毒性和伤口愈合作用，以及增强记忆、调节血脂谱、控制血糖和体重管理的益处。尽管该属分布广泛，化学成分多样，但对其生物活性的研究仍然有限。本综述的目的是总结 Science Direct、PubMed 和 Scopus 等数据库中关于 种属的生物活性化合物、传统用途和药理学特性的最相关数据。在搜索策略中使用了特定的关键词，包括“生物活性化合物”、“筋骨草属”、“唇形科”、“筋骨草提取物”、“筋骨草精油”、“传统用途”、“化学成分”、“治疗潜力”、“临床试验”、“体内研究”和“体外研究”。搜索策略是根据系统评价和荟萃分析的首选报告项目指南进行的。共纳入了 171 项研究的数据。本文强调了 种属的药物发现潜力，强调了它们在医学、化妆品、膳食补充剂和食品工业中的潜在应用。此外，它提供了有助于筋骨草研究计划的重要数据。
