Menu Iris, Ji Lanxin, Trentacosta Christopher J, Jacques Suzanne M, Qureshi Faisal, Thomason Moriah E
Department of Child & Adolescent Psychiatry, NYU Langone Health, New York, NY, USA.
Department of Psychology, Wayne State University, Detroit, MI, USA.
Child Neuropsychol. 2024 Nov 27:1-19. doi: 10.1080/09297049.2024.2434215.
Fetal inflammation, typically measured indirectly through prenatal maternal cytokine markers, has been shown to impact early childhood executive functions (EFs), which are central to later cognitive and life outcomes. Here, we assessed the impact of prenatal inflammation on EF developmental trajectories using direct placenta histopathology measures in 131 mothers who predominantly self-identified as Black (90.8% Black; 0.8% Asian American, 1.5% biracial, 0.8% Latinx, 3.1% White, 3.1% Missing). We found that placental measures of inflammation were associated with limited gain in EF development from 3 to 5 years old. In follow up analyses, we addressed whether screening questionnaires in infancy might aid in classification of infants as higher risk for subsequent EF problems. We found that parent responses to the Ages & Stages Questionnaire and the Infant/Toddler Sensory Profile at 12 months predict the development of EF abilities in children exposed to chronic inflammation. These findings open promising opportunities for early screening of children at risk for poor executive functioning in children exposed to prenatal inflammation.
胎儿炎症通常通过产前母体细胞因子标志物间接测量，已被证明会影响幼儿的执行功能（EFs），而执行功能对后期的认知和生活结果至关重要。在此，我们使用直接胎盘组织病理学测量方法，评估了产前炎症对131名主要自我认定为黑人的母亲（90.8%为黑人；0.8%为亚裔美国人，1.5%为混血儿，0.8%为拉丁裔，3.1%为白人，3.1%信息缺失）的EF发育轨迹的影响。我们发现，胎盘炎症测量与3至5岁时EF发育的有限增长有关。在后续分析中，我们探讨了婴儿期的筛查问卷是否有助于将婴儿分类为后续出现EF问题的高风险人群。我们发现，家长对12个月时的《年龄与阶段问卷》和《婴儿/幼儿感觉概况》的回答可预测暴露于慢性炎症的儿童的EF能力发展。这些发现为早期筛查暴露于产前炎症的儿童中执行功能差的风险儿童带来了有希望的机会。
