Natarajan A T, Darroudi F, Mullenders L H, Meijers M
Mutat Res. 1986 May;160(3):231-6. doi: 10.1016/0027-5107(86)90132-6.
Short treatment (up to 1 h) of cytosine arabinoside (araC) increases the frequencies of aberrations induced by X-rays in human lymphocytes, evaluated at the first mitosis following stimulation, or as prematurely condense chromosomes of G0 nuclei. Parallel biochemical experiments using nucleoid sedimentation technique, demonstrate that araC inhibits rejoining of DNA-strand breaks effectively. These results point out that X-ray-induced short-lived DNA strand breaks lead to chromosomal aberrations in human lymphocytes.
对阿糖胞苷（araC）进行短时间处理（长达1小时），会增加X射线在人类淋巴细胞中诱导的畸变频率，这一频率是在刺激后的第一次有丝分裂时评估的，或者是作为G0细胞核的早凝染色体来评估的。使用核小体沉降技术进行的平行生化实验表明，阿糖胞苷能有效抑制DNA链断裂的重新连接。这些结果指出，X射线诱导的短暂DNA链断裂会导致人类淋巴细胞中的染色体畸变。
