Sheldon Meagan, Ammons Michael, Nugent Kenneth
Internal Medicine/Pulmonary and Critical Care Medicine, Texas Tech University Health Sciences Center, Lubbock, USA.
Internal Medicine, Texas Tech University Health Sciences Center, Lubbock, USA.
Cureus. 2024 Oct 27;16(10):e72495. doi: 10.7759/cureus.72495. eCollection 2024 Oct.
The use of marijuana and cannabinoids is widespread throughout the United States, and these drugs can cause both acute and chronic medical disorders. The ingestion of edible products with uncertain content can cause accidental toxicity. The patient described in this case report ingested a large number of edible cannabinoid gummies. He developed a sequence of toxic states that included lethargy, agitation, vomiting, tachycardia, hypertension, acute respiratory failure, and elevated lactic acid levels. These clinical syndromes resolved over the next 24 hours with supportive intensive care unit management. The medical literature indicates that cannabis toxicity can cause acute lactic acidosis in some patients. This possibility needs to be considered when patients present to the emergency room with hypertension, tachycardia, and lactic acidosis.
大麻和大麻素在美国广泛使用，这些药物可导致急性和慢性医学病症。摄入成分不明的可食用产品可能会导致意外中毒。本病例报告中描述的患者摄入了大量含大麻素的可食用软糖。他出现了一系列中毒症状，包括嗜睡、烦躁、呕吐、心动过速、高血压、急性呼吸衰竭和乳酸水平升高。在接下来的24小时内，通过重症监护病房的支持性治疗，这些临床综合征得到缓解。医学文献表明，大麻中毒在一些患者中可导致急性乳酸性酸中毒。当患者因高血压、心动过速和乳酸性酸中毒就诊于急诊室时，需要考虑这种可能性。
