Inoue Masatoshi, Hiramatsu Miya, Kamegai Naoki, Yamamoto Junichiro
Department of Nephrology. Asahi University Hospital, 3-23 Hashimoto-cho, Gifu 500-8856, Japan.
Department of Nephrology. Nagoya University Graduate School of Medicine, Japan.
Toxicol Rep. 2025 Apr 26;14:102040. doi: 10.1016/j.toxrep.2025.102040. eCollection 2025 Jun.
The increasing availability of cannabidiol (CBD) products worldwide has raised concerns about their safety profile; although CBD is generally considered safe, adverse effects have been reported, particularly from overdose. This report describes a rare case of a 26-year-old male who ingested a small amount of CBD gummies (40 mg) and developed marked tachycardia, complete right bundle branch block (CRBBB), and lactic acidosis. The patient presented with nausea and vomiting, heart rate increased from a normal 80 bpm to 165 bpm, 12-lead ECG confirmed CRBBB, and laboratory tests showed elevated lactate levels indicative of type B lactic acidosis without shock or ischemia. Symptoms resolved with supportive care, including intravenous fluids, and the patient's cardiac conduction returned to normal within a week. This case highlights the potential for serious cardiovascular and metabolic complications from CBD gummy ingestion in Japan. These findings underscore the need for awareness among healthcare professionals of the potential side effects of CBD gummies, even in small doses. Close monitoring and supportive care are essential to manage these cases, and further research is needed to clarify the mechanisms of these effects and ensure the safety of CBD products.
全球范围内大麻二酚（CBD）产品的可获得性日益增加，引发了人们对其安全性的担忧；尽管CBD通常被认为是安全的，但已有不良反应的报道，尤其是过量摄入时。本报告描述了一例罕见病例，一名26岁男性摄入少量CBD软糖（40毫克）后出现明显心动过速、完全性右束支传导阻滞（CRBBB）和乳酸性酸中毒。患者出现恶心和呕吐，心率从正常的80次/分钟增至165次/分钟，12导联心电图证实为CRBBB，实验室检查显示乳酸水平升高，提示B型乳酸性酸中毒，无休克或缺血表现。通过包括静脉输液在内的支持性治疗，症状得以缓解，患者的心脏传导在一周内恢复正常。该病例凸显了在日本摄入CBD软糖可能引发严重心血管和代谢并发症的可能性。这些发现强调了医疗保健专业人员需要意识到CBD软糖即使小剂量摄入也可能产生的副作用。密切监测和支持性治疗对于处理这些病例至关重要，还需要进一步研究以阐明这些效应的机制并确保CBD产品的安全性。
