Batista Junior Almir Custodio, Maciel Lanaia Ítala Louzeiro, Rocha Yuri Arrates, Souza Gabriela Guimarães, Vaz Boniek Gontijo, Lopes Welber Daniel Zanetti, Botelho Ana Flávia Machado, Chalom Marc Yves, Chaves Andréa Rodrigues
Universidade Federal de Goiás, Instituto de Química, Goiânia, Goiás 74690-900, Brazil.
Universidade Federal de Goiás, Escola de Veterinária e Zootecnia, Goiânia, Goiás 74690-900, Brazil.
J Am Soc Mass Spectrom. 2025 Jan 1;36(1):201-208. doi: 10.1021/jasms.4c00422. Epub 2024 Nov 27.
This study introduces an alternative strategy for evaluating antiparasitic persistence compounds in cattle hair by Direct Analysis in Real Time Mass Spectrometry (DART-MS). The developed DART-MS method aimed to determine fenthion, chlorpyrifos, and cypermethrin in cattle hair samples. DART-MS analyses were performed in positive ion mode, and parameters related to the DART source were evaluated. The analytical performance demonstrated the efficiency of the optimized DART-MS method for fenthion, chlorpyrifos, and cypermethrin quantification in the evaluated samples, meeting criteria for precision, accuracy and limits of detection. Overall, the DART-MS method provided a fast and efficient analysis for determination of antiparasitic agents in cattle hair, which contributes to the evaluation of drug administration protocols and dosage intervals, and aids the safety and advancement of the livestock sector.
本研究介绍了一种通过实时直接分析质谱法（DART-MS）评估牛毛中抗寄生虫持久性化合物的替代策略。所开发的DART-MS方法旨在测定牛毛样品中的倍硫磷、毒死蜱和氯氰菊酯。DART-MS分析在正离子模式下进行，并评估了与DART源相关的参数。分析性能证明了优化后的DART-MS方法在评估样品中定量倍硫磷、毒死蜱和氯氰菊酯的效率，符合精密度、准确度和检测限标准。总体而言，DART-MS方法为测定牛毛中的抗寄生虫剂提供了快速有效的分析，有助于评估给药方案和给药间隔，并有助于畜牧业的安全与发展。
