Li Ying, Xiang Yajing, Chen Yuxi, Wang Yingying, Dong Wei, Liu Yan, Qi Xiaoliang, Shen Jianliang
School of Chemical Engineering, Nanjing University of Science & Technology, Nanjing, Jiangsu, 210094, China.
School & Hospital of Stomatology, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.
Macromol Biosci. 2025 Mar;25(3):e2400526. doi: 10.1002/mabi.202400526. Epub 2024 Nov 27.
Existing methods for treating diabetic oral ulcers often fall short in clinical environments due to potential bacterial contamination, oxidative harm, and hindered angiogenesis throughout the healing process. Here, a hydrogel patch (HYG2) have been developed for local in situ application. HYG2 comprises oxidized pullulan, quaternized chitosan, and eumelanin nanoparticles derived from cuttlefish ink. These components work together to efficiently heal wounds associated with diabetic oral ulcers. Application begins with a simple local injection that quickly forms a protective barrier over the mucosa, effectively stopping bleeding and counteracting inflammatory agents. HYG2 is distinguished by its strong antibacterial properties and capacity to eliminate reactive oxygen species, promoting bacteria clearance and managing oxidative stress, which accelerates the healing phase from inflammation to tissue regeneration. Additionally, HYG2's 3D structure, incorporating elements from natural sources, offers exemplary support for structural and nutritional cell needs. This enhancement fosters cell adhesion, migration, and proliferation, along with further angiogenesis during mucosal remodeling. Ultimately, HYG2 is fully absorbed by the body after serving its therapeutic functions. Evidence from in vitro and in vivo studies shows that HYG2 hydrogel markedly accelerates mucosal wound repair, making it a promising treatment for diabetic oral ulcers.
由于在整个愈合过程中存在潜在的细菌污染、氧化损伤和血管生成受阻等问题，现有的治疗糖尿病性口腔溃疡的方法在临床环境中往往效果不佳。在此，已开发出一种用于局部原位应用的水凝胶贴片（HYG2）。HYG2由氧化普鲁兰多糖、季铵化壳聚糖和源自乌贼墨的真黑素纳米颗粒组成。这些成分共同作用，能有效治愈与糖尿病性口腔溃疡相关的伤口。应用时先进行简单的局部注射，它会迅速在黏膜上形成一层保护屏障，有效止血并对抗炎症介质。HYG2的特点是具有强大的抗菌性能和消除活性氧的能力，可促进细菌清除并应对氧化应激，从而加速从炎症到组织再生的愈合阶段。此外，HYG2的三维结构融合了天然来源的元素，为细胞的结构和营养需求提供了理想的支持。这种增强作用促进了细胞黏附、迁移和增殖，以及黏膜重塑过程中的进一步血管生成。最终，HYG2在发挥治疗功能后会被人体完全吸收。体外和体内研究的证据表明，HYG2水凝胶能显著加速黏膜伤口修复，使其成为治疗糖尿病性口腔溃疡的一种有前景的疗法。
