Engineering Research Center of Western Resource Innovation Medicine Green Manufacturing, Ministry of Education, School of Chemical Engineering, Northwest University, Xi'an, 710069, China; Shaanxi Key Laboratory of Degradable Biomedical Materials and Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Xi'an, 710069, China; Biotech. & Biomed. Research Institute, Northwest University, Xi'an, 710069, China.
Engineering Research Center of Western Resource Innovation Medicine Green Manufacturing, Ministry of Education, School of Chemical Engineering, Northwest University, Xi'an, 710069, China; Shaanxi Key Laboratory of Degradable Biomedical Materials and Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Xi'an, 710069, China; Biotech. & Biomed. Research Institute, Northwest University, Xi'an, 710069, China; Xi'an Giant Biotechnology Co., Ltd., Xi'an, 710076, China.
Carbohydr Polym. 2025 Jan 1;347:122751. doi: 10.1016/j.carbpol.2024.122751. Epub 2024 Sep 15.
Chronic wounds caused by hyperglycaemia, hypoxia and bacterial infections are common complications in diabetic patients and chronic wound repair is extremely challenging in clinical practice. A series of hydrogels QPMP with good antioxidant and antimicrobial functions were prepared based on quaternized chitosan (QCS), oxidized pullulan polysaccharide (OP), dopamine-coated polypyrrole (PPY@PDA), and Chlorella vulgaris. The Schiff base cross-linking between the quaternized chitosan (QCS) and oxidized pullulan polysaccharide (OP) constitutes the basic skeleton of the hydrogel, and imparts a certain antimicrobial ability to the hydrogel. Chlorella vulgaris continuously produced oxygen under light conditions to relieve wound hypoxia and promote wound healing. The incorporation of PPY@PDA gave the hydrogel near-infrared (NIR) irradiation-assisted bactericidal activity and antioxidant activity, and as a conductive hydrogel, the hydrogel can be used to sense wound exudate and temperature changes, which can help to achieve the integration of diagnosis and treatment of wound healing. Most importantly, in a chronic wound model, the QPMP hydrogel was more effective in controlling the level of wound inflammation and promoting collagen deposition, angiogenesis, and early wound closure compared to the HeraDerm dressing. Therefore, this conductive oxygen-producing hydrogel is extremely beneficial for chronic wound healing in diabetes.
高血糖、缺氧和细菌感染引起的慢性伤口是糖尿病患者的常见并发症，慢性伤口修复在临床实践中极具挑战性。基于季铵化壳聚糖（QCS）、氧化普鲁兰多糖（OP）、多巴胺包覆的聚吡咯（PPY@PDA）和小球藻制备了一系列具有良好抗氧化和抗菌功能的水凝胶 QPMP。季铵化壳聚糖（QCS）和氧化普鲁兰多糖（OP）之间的席夫碱交联构成了水凝胶的基本骨架，并赋予水凝胶一定的抗菌能力。小球藻在光照条件下持续产生氧气，以缓解伤口缺氧并促进伤口愈合。PPY@PDA 的加入赋予水凝胶近红外（NIR）辐射辅助杀菌活性和抗氧化活性，并且作为导电水凝胶，水凝胶可以用于感测伤口渗出物和温度变化，这有助于实现伤口愈合的诊断和治疗一体化。最重要的是，在慢性伤口模型中，QPMP 水凝胶在控制伤口炎症水平和促进胶原沉积、血管生成和早期伤口闭合方面比 HeraDerm 敷料更有效。因此，这种导电产氧水凝胶对糖尿病慢性伤口愈合极为有益。
