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食管癌中的细胞外囊泡:功能与治疗前景。

Exosomes in esophageal cancer: function and therapeutic prospects.

机构信息

Medical School, Kunming University of Science and Technology, Kunming, 650500, China.

出版信息

Med Oncol. 2024 Nov 27;42(1):18. doi: 10.1007/s12032-024-02543-x.

Abstract

Esophageal cancer (EC) is one of the most common malignant tumors worldwide. Exosomes are a type of extracellular vesicles produced by eukaryotic cells and present in all body fluids. Recent studies have revealed that exosomes can be used as a tool for cell signaling and have great potential in cancer diagnosis and treatment strategies. This article reviews the research progress of exosomes in EC in recent years, mainly including the mechanism of action, diagnostic markers, therapeutic targets, and drug carriers. The challenges faced are discussed to provide guidelines for further research in future.

摘要

食管癌(EC)是全球最常见的恶性肿瘤之一。外泌体是真核细胞产生的一类细胞外囊泡,存在于所有体液中。最近的研究表明,外泌体可用作细胞信号传递的工具,在癌症诊断和治疗策略方面具有巨大的潜力。本文综述了近年来外泌体在食管癌中的研究进展,主要包括作用机制、诊断标志物、治疗靶点和药物载体。讨论了所面临的挑战,为未来的进一步研究提供了指导。

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