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Metabolic Breakdown: The Hidden Role of Endothelial Glycolysis in Kidney Fibrosis.

作者信息

Kapitsinou Pinelopi P

机构信息

Feinberg Cardiovascular & Renal Research Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois; and Division of Nephrology and Hypertension, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

出版信息

J Am Soc Nephrol. 2025 Jan 1;36(1):1-3. doi: 10.1681/ASN.0000000568. Epub 2024 Nov 27.

DOI:10.1681/ASN.0000000568
PMID:39602365
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11706547/
Abstract
摘要

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本文引用的文献

1
Postischemic inactivation of HIF prolyl hydroxylases in endothelium promotes maladaptive kidney repair by inducing glycolysis.内皮细胞中缺氧诱导因子脯氨酰羟化酶的缺血后失活通过诱导糖酵解促进适应性不良的肾脏修复。
J Clin Invest. 2024 Dec 2;135(3):e176207. doi: 10.1172/JCI176207.
2
Glycolysis in Peritubular Endothelial Cells and Microvascular Rarefaction in CKD.肾小管周围内皮细胞中的糖酵解与慢性肾脏病中的微血管稀疏化
J Am Soc Nephrol. 2025 Jan 1;36(1):19-33. doi: 10.1681/ASN.0000000000000488. Epub 2024 Sep 3.
3
Pentose Pathway Activation Is Superior to Increased Glycolysis for Therapeutic Angiogenesis in Peripheral Arterial Disease.戊糖磷酸途径激活优于增加糖酵解促进外周动脉疾病的治疗性血管生成。
J Am Heart Assoc. 2023 Apr 4;12(7):e027986. doi: 10.1161/JAHA.122.027986. Epub 2023 Mar 28.
4
IGFBP5 promotes diabetic kidney disease progression by enhancing PFKFB3-mediated endothelial glycolysis.IGFBP5 通过增强 PFKFB3 介导的内皮糖酵解促进糖尿病肾病进展。
Cell Death Dis. 2022 Apr 13;13(4):340. doi: 10.1038/s41419-022-04803-y.
5
Immunometabolic Endothelial Phenotypes: Integrating Inflammation and Glucose Metabolism.免疫代谢型内皮表型：炎症与糖代谢的整合
Circ Res. 2021 Jun 25;129(1):9-29. doi: 10.1161/CIRCRESAHA.120.318805. Epub 2021 Apr 23.
6
Single-Cell RNA Sequencing Reveals Renal Endothelium Heterogeneity and Metabolic Adaptation to Water Deprivation.单细胞 RNA 测序揭示了肾脏内皮细胞的异质性和对水剥夺的代谢适应。
J Am Soc Nephrol. 2020 Jan;31(1):118-138. doi: 10.1681/ASN.2019080832. Epub 2019 Dec 9.
7
Hallmarks of Endothelial Cell Metabolism in Health and Disease.内皮细胞代谢的健康与疾病特征。
Cell Metab. 2019 Sep 3;30(3):414-433. doi: 10.1016/j.cmet.2019.08.011.
8
PFKFB3-mediated endothelial glycolysis promotes pulmonary hypertension.PFKFB3 介导的内皮细胞糖酵解促进肺动脉高压。
Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13394-13403. doi: 10.1073/pnas.1821401116. Epub 2019 Jun 18.
9
Role of PFKFB3-driven glycolysis in vessel sprouting.PFKFB3 驱动的糖酵解在血管发芽中的作用。
Cell. 2013 Aug 1;154(3):651-63. doi: 10.1016/j.cell.2013.06.037.
10
The role of capillary density, macrophage infiltration and interstitial scarring in the pathogenesis of human chronic kidney disease.毛细血管密度、巨噬细胞浸润和间质纤维化在人类慢性肾脏病发病机制中的作用。
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