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新生儿戒断综合征的产前和产后筛查与检测

Pre-natal and post-natal screening and testing in neonatal abstinence syndrome.

作者信息

Ostfeld-Johns Sharon

机构信息

Yale University School of Medicine, Department of Pediatrics, Section of Hospital Medicine, United States.

出版信息

Semin Perinatol. 2025 Feb;49(1):152009. doi: 10.1016/j.semperi.2024.152009. Epub 2024 Nov 22.

Abstract

The way we enact screening for substance use during pregnancy within our healthcare systems can work by decreasing stigma, promoting engagement, and supporting people with reaching the end of their pregnancy in a manner where the newborn can be well supported. The way we enact biochemical specimen toxicology testing for substance use during pregnancy and in newborns contributes to increased stigma, disengagement from care, and potential continuation of uncontrolled substance use up until delivery such that the newborn may not be able to be well supported in the family environment. These effects are inequitably distributed, leading to worse outcomes for families of color and families living in poverty. Serial screening with a validated questionnaire starting at the first prenatal visit and continuing through the delivery hospitalization should occur and be followed up with service connections and substance use disorder diagnosis and treatment. Newborn toxicology testing as a diagnostic tool for risk of withdrawal or the etiology of potential withdrawal symptoms represents a failure in the effectiveness of compassionate communication by healthcare providers with the birthing person. Given the current level of evidence of clinical utility and the inequitable consequences specific to these tests, they are rarely needed.

摘要

我们在医疗系统中开展孕期药物使用筛查的方式,可以通过减少污名化、促进参与,并支持人们以一种能为新生儿提供良好支持的方式度过孕期。而我们对孕期及新生儿进行药物使用生化样本毒理学检测的方式,却导致了污名化加剧、脱离医疗护理,以及在分娩前药物使用失控的情况可能持续存在,以至于新生儿在家庭环境中可能无法得到良好的支持。这些影响分布不均,导致有色人种家庭和贫困家庭的结局更糟。应从首次产前检查开始,持续到分娩住院期间,使用经过验证的问卷进行系列筛查,并随后进行服务对接以及药物使用障碍的诊断和治疗。将新生儿毒理学检测作为戒断风险或潜在戒断症状病因的诊断工具,表明医疗服务提供者在与产妇进行富有同情心的沟通方面效果不佳。鉴于目前临床效用的证据水平以及这些检测所特有的不公平后果,它们很少有必要进行。

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