Tang Shaoxin, Feng Keru, Yang Rui, Cheng Yang, Chen Meiyue, Zhang Hui, Shi Nianyuan, Wei Zhao, Ren Hui, Ma Yufei
The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, P. R. China.
Bioinspired Engineering and Biomechanics Center (BEBC), School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, P. R. China.
Adv Healthc Mater. 2025 Jan;14(2):e2403734. doi: 10.1002/adhm.202403734. Epub 2024 Nov 27.
Adhesive hydrogels characterized by structural properties similar to the extracellular matrix, excellent biocompatibility, controlled degradation, and tunable mechanical properties have demonstrated significant potential in biomedical applications, including tissue engineering, biosensors, and drug delivery systems. These hydrogels exhibit remarkable adhesion to target substrates and can be rationally engineered to meet specific requirements. In recent decades, adhesive hydrogels have experienced significant advancements driven by the introduction of numerous multifunctional design strategies. This review initially summarizes the chemical bond-based design strategies for tissue adhesion, encompassing static covalent bonds, dynamic covalent bonds, and non-covalent interactions. Subsequently, the multiple functionalities imparted by these diverse design strategies, including highly stretchable and tough performances, responsiveness to microenvironments, anti-freezing/heating properties, conductivity, antibacterial activity, and hemostatic properties are discussed. In addition, recent advances in the biomedical applications of adhesive hydrogels, focusing on tissue repair, drug delivery, medical devices, and wearable sensors are reviewed. Finally, the current challenges are highlighted and future trends in this rapidly evolving field are discussed.
具有与细胞外基质相似的结构特性、优异的生物相容性、可控降解性和可调机械性能的粘性水凝胶在生物医学应用中已显示出巨大潜力，包括组织工程、生物传感器和药物输送系统。这些水凝胶对目标底物表现出显著的粘附性，并且可以合理设计以满足特定要求。近几十年来，由于引入了众多多功能设计策略，粘性水凝胶取得了重大进展。本综述首先总结了基于化学键的组织粘附设计策略，包括静态共价键、动态共价键和非共价相互作用。随后，讨论了这些不同设计策略赋予的多种功能，包括高拉伸性和韧性、对微环境的响应性、抗冻/热性能、导电性、抗菌活性和止血性能。此外，还综述了粘性水凝胶在生物医学应用方面的最新进展，重点是组织修复、药物输送、医疗设备和可穿戴传感器。最后，强调了当前的挑战，并讨论了这个快速发展领域的未来趋势。
