Zhang Hongtao, Yuan Shiguo, Zheng Boyuan, Wu Peng, He Xiuming, Zhao Yi, Zhong Zhangfeng, Zhang Xiaofang, Guan Jian, Wang Huajun, Yang Lei, Zheng Xiaofei
Department of Orthopedics, Zhongshan Torch Development Zone People's Hospital, Zhongshan, 528437, P. R. China.
Department of Orthopaedic, Hainan Hospital, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Haikou, 570203, P. R. China.
Small. 2025 Jan;21(3):e2407885. doi: 10.1002/smll.202407885. Epub 2024 Nov 27.
Osteoarthritis (OA) is a progressively developing condition primarily characterized by the deterioration of articular cartilage and the proliferation of bone, along with ongoing inflammation. Although the precise pathogenesis remains somewhat elusive, restoring the homeostatic balance of the intra-articular microenvironment is crucial for the management of OA. Intra-articular injection of medication is one of the most direct and effective treatment methods; however, most injectable drugs used for osteoarthritis treatment, due to their rapid breakdown, quick release, poor biological activity, and frequent injections, leading to increased risk of infection and suboptimal therapeutic outcomes. In this study, a lubricating and dual-responsive injectable hydrogel based on zeolitic imidazolate frameworks-8 (ZIF-8) impregnated with Quercetin (Que) is designed, which can facilitate OA treatment by remodeling the microenvironment. The prepared injectable nanocomposite hydrogel (MH/CCM@ZIF-8@Que) exhibits pH and reactive oxygen species (ROS) responsiveness, alongside a controllable release of bioactive substances to modulate the microenvironment of bone tissue, thereby mitigating synovitis and the degeneration of cartilage matrix, while simultaneously facilitating cartilage repair. This developed thermosensitive injectable hydrogel, which effectively balances lubrication with the controlled release of bioactive substances, represents a highly promising therapeutic approach for osteoarthritis.
骨关节炎（OA）是一种渐进性发展的病症，主要特征为关节软骨退变、骨质增生以及持续的炎症。尽管其确切发病机制仍有些难以捉摸，但恢复关节内微环境的稳态平衡对于OA的治疗至关重要。关节腔内注射药物是最直接有效的治疗方法之一；然而，大多数用于骨关节炎治疗的可注射药物，由于其快速分解、快速释放、生物活性差以及频繁注射，导致感染风险增加且治疗效果欠佳。在本研究中，设计了一种基于负载槲皮素（Que）的沸石咪唑酯骨架-8（ZIF-8）的润滑且双响应可注射水凝胶，其可通过重塑微环境促进OA治疗。制备的可注射纳米复合水凝胶（MH/CCM@ZIF-8@Que）表现出pH和活性氧（ROS）响应性，同时生物活性物质可控释放以调节骨组织微环境，从而减轻滑膜炎和软骨基质退变，同时促进软骨修复。这种开发的热敏可注射水凝胶有效平衡了润滑与生物活性物质的控释，是一种极有前景的骨关节炎治疗方法。
