Department of Nephrology, Chongqing Emergency Medical Center, Chongqing University Central Hospital, No.1 Health Road, LiangLukou, Yuzhong District, Chongqing City, 400014, China.
Chongqing Emergency Medical Center, School of Medicine of Chongqing University, Chongqing University Central Hospital, Chongqing City, China.
BMC Nephrol. 2024 Nov 27;25(1):427. doi: 10.1186/s12882-024-03875-6.
The primary aim of this study is to explore the relationship between serum levels of LOX-1, hs-cTnT, and NGAL, and renal function in patients with CKD, as well as to evaluate their diagnostic value for early detection and monitoring of disease progression in CKD patients.
A retrospective study was conducted on 108 patients with chronic kidney disease admitted to our hospital from January 2023 to December 2023. The patients were divided into the mild renal insufficiency group (51 cases) and the severe renal insufficiency group (57 cases). The differences in serum levels of LOX-1, hs-cTnT, and NGAL between the two groups were compared, and Pearson correlation analysis was used to explore the relationship between the three levels and renal function. ROC analysis was used to evaluate the predictive value of the three markers for the diagnosis of CKD.
The levels of LOX-1, hs-cTnT, and NGAL in the mild renal insufficiency group were lower than those in the severe renal insufficiency group (P < 0.05). Correlation analysis showed that serum levels of LOX-1, hs-cTnT, and NGAL were positively correlated with the deterioration of renal function (P < 0.001), indicating a significant correlation between LOX-1, hs-cTnT, NGAL levels, and the deterioration of renal function. ROC analysis showed that the AUC of serum levels of LOX-1, hs-cTnT, and NGAL were 0.859, 0.882, and 0.841, indicating a significant predictive value for the diagnosis of chronic kidney disease.
Serum levels of LOX-1, hs-cTnT, NGAL, and related markers demonstrate a direct association with the extent of renal impairment, offering predictive capabilities for diagnosing CKD.
本研究的主要目的是探讨血清 LOX-1、hs-cTnT 和 NGAL 水平与慢性肾脏病（CKD）患者肾功能之间的关系，并评估它们对 CKD 患者早期发现和疾病进展监测的诊断价值。
对 2023 年 1 月至 12 月我院收治的 108 例慢性肾脏病患者进行回顾性研究。将患者分为轻度肾功能不全组（51 例）和重度肾功能不全组（57 例）。比较两组患者血清 LOX-1、hs-cTnT 和 NGAL 水平的差异，采用 Pearson 相关分析探讨三者水平与肾功能的关系。采用 ROC 分析评价三者标志物对 CKD 诊断的预测价值。
轻度肾功能不全组 LOX-1、hs-cTnT 和 NGAL 水平均低于重度肾功能不全组（P<0.05）。相关性分析显示，血清 LOX-1、hs-cTnT 和 NGAL 水平与肾功能恶化呈正相关（P<0.001），表明 LOX-1、hs-cTnT、NGAL 水平与肾功能恶化之间存在显著相关性。ROC 分析显示，血清 LOX-1、hs-cTnT 和 NGAL 水平的 AUC 分别为 0.859、0.882 和 0.841，对慢性肾脏病的诊断具有显著的预测价值。
血清 LOX-1、hs-cTnT、NGAL 及相关标志物与肾功能损害程度直接相关，对 CKD 的诊断具有预测能力。
