Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
Cardiology Department, Shiraz University of Medical Science of Iran, Shiraz, Iran.
BMC Endocr Disord. 2024 Nov 27;24(1):257. doi: 10.1186/s12902-024-01791-2.
Metabolic syndrome is a prevalent and common health problem and numerous studies have revealed the role of diet and lifestyle change in prevention of metabolic syndrome. However, the novel dietary index, cardioprotective index (CPI) and its association with metabolic syndrome is not investigated yet. In the current study, we evaluated the association between metabolic syndrome and its components, CPI, Nesfatin-1 and Omentin-1in a cross-sectional study.
Three hundred forty eight overweight and obese individuals with metabolic syndrome were recruited. Subjects underwent anthropometric and laboratory assays including metabolic markers, Nesfatin-1 and Omentin-1 with commercial kits.
Those at the first tertile of CPI had lower high density lipoprotein concentrations (HDL) and higher low density lipoprotein concentrations (LDL), triglyceride (TG), systolic and diastolic blood pressures (SBP, DBP) levels compared with those at the highest tertiles (P < 0.05). After adjustment for the confounding effects of age, sex, body mass index, physical activity and total calorie intake, LDL lost its significance across CPI tertiles. Moreover, serum total cholesterol, insulin and insulin resistance were not significant across CPI tertiles neither in crude nor in adjusted models (P > 0.05). Additionally, being at the third tertile of CPI was accompanied with significantly higher Nesfatin-1 and Omentin-1 levels compared with lowest tertiels (P < 0.05) in crude and confounder - adjusted models.
To our findings, CPI was in positive relationship with metabolic parameters, blood pressure, Nesfatin-1 and Omentin-1 levels in metabolic syndrome. Further future studies will help to elaborate the causality.
Not applicable.
代谢综合征是一种普遍且常见的健康问题，许多研究已经揭示了饮食和生活方式改变在预防代谢综合征中的作用。然而，新的饮食指数，心脏保护指数（CPI）及其与代谢综合征的关系尚未被研究。在本研究中，我们评估了代谢综合征及其各组成部分、CPI、Nesfatin-1 和 Omentin-1 之间的相关性，这是一项横断面研究。
共招募了 348 名超重和肥胖的代谢综合征患者。对受试者进行了人体测量学和实验室检测，包括代谢标志物、Nesfatin-1 和 Omentin-1，采用商业试剂盒进行检测。
与最高三分位数相比，CPI 第一三分位数的高密度脂蛋白（HDL）浓度较低，而低密度脂蛋白（LDL）、甘油三酯（TG）、收缩压（SBP）和舒张压（DBP）水平较高（P<0.05）。在校正年龄、性别、体重指数、体力活动和总热量摄入等混杂因素的影响后，LDL 在 CPI 三分位数中失去了意义。此外，在未校正和校正模型中，总胆固醇、胰岛素和胰岛素抵抗在 CPI 三分位数中均无显著差异（P>0.05）。此外，在未校正和校正模型中，CPI 第三三分位数的血清 Nesfatin-1 和 Omentin-1 水平显著高于最低三分位数（P<0.05）。
根据我们的研究结果，CPI 与代谢综合征的代谢参数、血压、Nesfatin-1 和 Omentin-1 水平呈正相关。进一步的未来研究将有助于阐明因果关系。
不适用。
