在肥胖成年人中，腹部容积指数与较高的氧化型低密度脂蛋白、高血压以及较低的高密度脂蛋白有关。

Abdominal volume index is associated with higher oxidized LDL, high blood pressure and lower HDL among obese adults.

作者信息

Alanazi Mansuor Ahmed, Alshehri Khaled, Alerwy Faisal H, Alrasheed Tariq, Lahza Hassan Fareed M, Aref Albezrah Nisreen Khalid, Alghabban Yazeed Ibrahim, Mohammed Abdulghani Mahfoudh Almusali

机构信息

Department of Family Medicine, University of Tabuk, Tabuk, Saudi Arabia.

Department of Internal Medicine, University of Tabuk, Tabuk, 47713, Saudi Arabia.

出版信息

BMC Endocr Disord. 2025 Feb 28;25(1):56. doi: 10.1186/s12902-025-01884-6.

DOI:10.1186/s12902-025-01884-6

PMID:40016702

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11869561/

Abstract

OBJECTIVES

Central obesity is a well-known risk factor of numerous disease. Numerous indicators are developed for central obesity measurement, among them, abdominal volume index (AVI), reflecting total volume of the abdomen, precisely estimates the visceral fat volume. As a relatively new health measure and potent prognostic marker of metabolic disturbances, no study is available to investigate its role in cardio-metabolic health and oxidized LDL among obese young adults. In the current study we aimed to evaluate the association between abdominal volume index (AVI) with cardio-metabolic profile including serum lipids, glycemic markers of serum glucose, hemoglobin (Hb) AC, insulin, oxidized LDL and blood pressure among young obese adults.

METHODS

Two hundred twenty young adults aged 18 to 25 years old with overweight or obesity were enrolled in the current study. Anthropometric measurements were done and AVI were calculated. Biochemical variables including serum total cholesterol (TC), low density lipoprotein cholesterol (LDL), high density lipoprotein cholesterol (HDL), triglyceride (TG), glycemic markers, including fasting serum glucose (FBS), insulin, hemoglobin (Hb) AC and blood pressure were also measured with an automatic analyzer.

RESULTS

Participants in the third tertiles of AVI had higher body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR) (p < 0.001 for all). Among biochemical variables, oxidized LDL, TG and HDL demonstrated significant associations across AVI tertiles in the first and second models, with higher oxidized LDL and TG and lower HDL levels observed in higher AVI tertiles (p < 0.05). Moreover, those at the highest AVI tertiles showed significantly higher odds ratios for elevated cardio-metabolic index and systolic and diastolic blood pressures compared to the first tertiles (p < 0.05).

CONCLUSIONS

In the current study, we comprehensively investigated the association between AVI with cardio-metabolic health in young obese adults and accordingly, AVI was unfavorably associated with metabolic health among obese adults. Further studies are needed to elaborate the underlying mechanisms.

CLINICAL TRIAL NUMBER

Not applicable.

摘要

目的

中心性肥胖是众多疾病的一个众所周知的危险因素。为测量中心性肥胖已开发出许多指标，其中，反映腹部总体积的腹部容积指数（AVI）能精确估计内脏脂肪体积。作为一种相对较新的健康指标和代谢紊乱的有力预后标志物，尚无研究探讨其在肥胖青年人心血管代谢健康和氧化型低密度脂蛋白（ox-LDL）方面的作用。在本研究中，我们旨在评估肥胖青年成年人的腹部容积指数（AVI）与心血管代谢指标之间的关联，这些指标包括血脂、血糖指标、糖化血红蛋白（Hb）AC、胰岛素、氧化型低密度脂蛋白和血压。

方法

本研究纳入了220名年龄在18至25岁之间的超重或肥胖青年成年人。进行了人体测量并计算了AVI。还使用自动分析仪测量了生化变量，包括血清总胆固醇（TC）、低密度脂蛋白胆固醇（LDL）、高密度脂蛋白胆固醇（HDL）、甘油三酯（TG）、血糖指标，包括空腹血清葡萄糖（FBS）、胰岛素、糖化血红蛋白（Hb）AC以及血压。

结果

AVI处于第三个三分位数的参与者具有更高的体重指数（BMI）、腰围（WC）、腰臀比（WHR）和腰高比（WHtR）（所有p值均<0.001）。在生化变量中，氧化型低密度脂蛋白、TG和HDL在第一个和第二个模型中显示出与AVI三分位数之间存在显著关联，在较高的AVI三分位数中观察到氧化型低密度脂蛋白和TG水平较高，HDL水平较低（p<0.05）。此外，与第一个三分位数相比，AVI最高三分位数的参与者出现心血管代谢指数升高以及收缩压和舒张压升高的优势比显著更高（p<0.05）。