Department of Pediatrics, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Acta Paediatr. 2017 Nov;106(11):1851-1856. doi: 10.1111/apa.14026.
There have been very few paediatric studies on omentin-1, an anti-inflammatory adipokine that provides a link between adiposity, insulin resistance and metabolic syndrome. This Chinese study evaluated the association between omentin-1 and metabolic syndrome and analysed the effect of a six-month lifestyle intervention on the levels in obese children.
We recruited 119 obese outpatients (75% boys) aged 7-18 years from the Second Affiliated Hospital of Xi'an Jiaotong University, who underwent a six- month lifestyle intervention. Our controls were 55 matched children with normal weight. Anthropometric parameters, biochemical data and circulating omentin-1 levels were measured at baseline and after six months.
Of the 119 obese children, 32 (27%) had metabolic syndrome. The obese children, particularly those with metabolic syndrome, had significantly lower serum omentin-1 levels at baseline than the controls. We also found that the omentin-1 levels were negatively associated with their body mass index, waist circumference and homoeostasis model assessment of insulin resistance. After the six-month lifestyle intervention, the obese children showed significant weight loss and their omentin-1 levels increased.
Serum omentin-1 was regulated by weight and seemed to be associated with children's metabolic disorders. A six-month lifestyle intervention significantly increased serum omentin-1 levels.
很少有关于网膜素-1 的儿科研究，网膜素-1 是一种抗炎脂肪因子，它将肥胖、胰岛素抵抗和代谢综合征联系起来。这项中国研究评估了网膜素-1 与代谢综合征之间的关系，并分析了为期六个月的生活方式干预对肥胖儿童网膜素-1 水平的影响。
我们招募了来自西安交通大学第二附属医院的 119 名肥胖门诊患者（75%为男性），年龄在 7-18 岁之间，他们接受了为期六个月的生活方式干预。我们的对照组是 55 名匹配的正常体重儿童。在基线和六个月后测量了人体测量参数、生化数据和循环网膜素-1 水平。
在 119 名肥胖儿童中，有 32 名（27%）患有代谢综合征。肥胖儿童，特别是患有代谢综合征的儿童，其血清网膜素-1水平明显低于对照组。我们还发现，网膜素-1水平与他们的体重指数、腰围和稳态模型评估的胰岛素抵抗呈负相关。经过六个月的生活方式干预，肥胖儿童体重明显减轻，网膜素-1水平升高。
血清网膜素-1受体重调节，似乎与儿童代谢紊乱有关。为期六个月的生活方式干预显著增加了血清网膜素-1水平。
