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对硝基呋喃妥因抗生素耐药性耐久性的见解。

Insights into durability against resistance from the antibiotic nitrofurantoin.

作者信息

Kettlewell Riannah, Jones Charlotte, Felton Timothy W, Lagator Mato, Gifford Danna R

机构信息

Division of Evolution, Infection & Genomics, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.

Division of Immunology, Immunity to Infection & Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.

出版信息

NPJ Antimicrob Resist. 2024;2(1):41. doi: 10.1038/s44259-024-00056-1. Epub 2024 Nov 25.

DOI:10.1038/s44259-024-00056-1
PMID:39605872
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11588651/
Abstract

Nitrofurantoin has shown exceptional durability against resistance over 70 years of use. This longevity stems from factors such as rapid achievement of therapeutic concentrations, multiple physiological targets against bacteria, low risk of horizontal gene transfer, and the need to acquire multiple mutations to achieve resistance. These combined features limit resistance emergence and spread of nitrofurantoin resistance. We propose nitrofurantoin as an exemplar for developing other durable treatments.

摘要

在长达70多年的使用过程中，呋喃妥因已显示出对耐药性具有非凡的耐受性。这种长期有效性源于多种因素，如能迅速达到治疗浓度、对细菌有多个生理靶点、水平基因转移风险低，以及需要获得多个突变才能产生耐药性。这些综合特性限制了呋喃妥因耐药性的出现和传播。我们建议将呋喃妥因作为开发其他持久有效治疗方法的范例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10c9/11721092/112ac228ce20/44259_2024_56_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10c9/11721092/112ac228ce20/44259_2024_56_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10c9/11721092/112ac228ce20/44259_2024_56_Fig1_HTML.jpg

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