Zhang Deju, Yuan Ying, Xiong Juan, Zeng Qingdong, Gan Yiming, Jiang Kai, Xie Ni
Biobank, Shenzhen Second People's Hospital, First Affiliated Hospital of Shenzhen University, Shenzhen, China.
Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen, China.
Front Pharmacol. 2024 Nov 13;15:1486264. doi: 10.3389/fphar.2024.1486264. eCollection 2024.
Breast cancer is the most frequently diagnosed and fatal cancer among women worldwide. Dairy protein-derived peptides and dairy products are important parts of the daily human diet and have shown promising activities in suppressing the proliferation, migration, and invasion of breast cancer cells, both and . Most of the review literature employs meta-analysis methods to explore the association between dairy intake and breast cancer risk. However, there is a lack of comprehensive summary regarding the anti-breast cancer properties of dairy protein-derived peptides, dairy products, and dairy protein-based nanoparticles as well as their underlying mechanisms of action. Therefore, the present study discussed the breast cancer inhibitory effects and mechanisms of active peptides derived from various dairy protein sources. Additionally, the characteristics, anti-breast cancer activities and active components of several types of dairy products, including fermented milk, yogurt and cheeses, were summarized. Furthermore, the preparation methods and therapeutic effects of various dairy protein-containing nanoparticle delivery systems for breast cancer therapy were briefly described. Lastly, this work also provided an overview of what is currently known about the anti-breast cancer effects of dairy products in clinical studies. Our review will be of interest to the development of natural anticancer drugs.
乳腺癌是全球女性中最常被诊断出且致死率最高的癌症。乳源蛋白衍生肽和乳制品是人类日常饮食的重要组成部分，并且在抑制乳腺癌细胞的增殖、迁移和侵袭方面已显示出有前景的活性，体内和体外实验均如此。大多数综述文献采用荟萃分析方法来探究乳制品摄入与乳腺癌风险之间的关联。然而，关于乳源蛋白衍生肽、乳制品和基于乳蛋白的纳米颗粒的抗乳腺癌特性及其潜在作用机制，缺乏全面的总结。因此，本研究讨论了源自各种乳源蛋白的活性肽的乳腺癌抑制作用及其机制。此外，还总结了几种类型的乳制品（包括发酵乳、酸奶和奶酪）的特性、抗乳腺癌活性和活性成分。此外，还简要描述了用于乳腺癌治疗的各种含乳蛋白纳米颗粒递送系统的制备方法和治疗效果。最后，这项工作还概述了目前临床研究中关于乳制品抗乳腺癌作用的已知情况。我们的综述将对天然抗癌药物的开发具有重要意义。
