An Seokyung, Gunathilake Madhawa, Kim Jeongseon
Department of Cancer AI and Digital Health, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang-Si, South Korea.
Department of Cancer AI and Digital Health, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang-Si, South Korea.
Nutr Res. 2025 Jun;138:68-75. doi: 10.1016/j.nutres.2025.02.003. Epub 2025 Feb 27.
Breast cancer (BC) is a prevalent global health concern, with various risk factors contributing to its heterogeneity. This comprehensive meta-analysis aims to explore the association between dairy consumption and BC risk, stratified by hormone receptor, menopausal status, and age. To assess the association between dairy consumption and BC risk, a systematic literature review based on studies published until December 2024 retrieved from PubMed, SCOPUS, Web of Science, and Cochrane Library. Summary relative risks (RRs) with corresponding 95% confidence intervals (CIs) were calculated and then aggregated using random-effects models. Summary RR from 51 studies with 62,602 BC cases showed that overall dairy consumption is inversely associated with BC risk (RR = 0.91, 95% CI: 0.84-0.98, I = 75%), particularly among individuals aged over 45 (RR = 0.81, 95% CI: 0.68-0.98, I = 0%). Notably, higher intake of low-fat dairy products showed potential protective effects (RR = 0.91, 95% CI: 0.84-0.98, I = 56%), especially in premenopausal women (skimmed milk, RR = 0.86, 95% CI: 0.76-0.97, I = 0%). Fermented dairy products, including yogurt, exhibited a decreased BC risk, particularly in postmenopausal women (RR = 0.91, 95% CI: 0.87-0.96, I = 0%). However, a positive association was observed between total milk intake and the risk of estrogen receptor-negative BC (RR = 1.31, 95% CI: 1.08-1.59, I = 0%). This meta-analysis provides comprehensive insights into the association between specific dairy product consumption and BC risk. The findings highlight the protective impact of specific dairy products on different subtypes, offering valuable insights for BC prevention.
乳腺癌（BC）是一个全球普遍关注的健康问题，多种风险因素导致其具有异质性。这项全面的荟萃分析旨在探讨乳制品消费与乳腺癌风险之间的关联，并按激素受体、绝经状态和年龄进行分层。为评估乳制品消费与乳腺癌风险之间的关联，我们基于截至2024年12月发表的研究进行了系统的文献综述，这些研究来自PubMed、SCOPUS、Web of Science和Cochrane图书馆。计算了汇总相对风险（RRs）及相应的95%置信区间（CIs），然后使用随机效应模型进行汇总。来自51项研究、共62,602例乳腺癌病例的汇总RR显示，总体乳制品消费与乳腺癌风险呈负相关（RR = 0.91，95% CI：0.84 - 0.98，I² = 75%），尤其是在45岁以上的人群中（RR = 0.81，95% CI：0.68 - 0.98，I² = 0%）。值得注意的是，较高的低脂乳制品摄入量显示出潜在的保护作用（RR = 0.91，95% CI：0.84 - 0.98，I² = 56%），特别是在绝经前女性中（脱脂牛奶，RR = 0.86，95% CI：0.76 - 0.97，I² = 0%）。包括酸奶在内的发酵乳制品显示出乳腺癌风险降低，特别是在绝经后女性中（RR = 0.91，95% CI：0.87 - 0.96，I² = 0%）。然而，总牛奶摄入量与雌激素受体阴性乳腺癌风险之间存在正相关（RR = 1.31，95% CI：1.08 - 1.59，I² = 0%）。这项荟萃分析为特定乳制品消费与乳腺癌风险之间的关联提供了全面的见解。研究结果突出了特定乳制品对不同亚型的保护作用，为乳腺癌预防提供了有价值的见解。
