Anderson D E, Murphy P, Kearns W
Pavlov J Biol Sci. 1986 Jan-Mar;21(1):25-31. doi: 10.1007/BF02995040.
Avoidance conditioning sessions and isotonic saline (1.3 L/day) were administered to dogs for 12 days under conditions of a low (0.1%) or high (1.5%) calcium diet. Twenty-four-hour mean arterial pressure increased comparably during the stress-salt conditioning periods on both the low (systolic: +16 +/- 5 mm Hg; diastolic: +6 +/- 2 mm Hg) and high (systolic: +17 +/- 4 mm Hg; diastolic: +11 +/- 4 mm Hg) calcium diets. Urine volume, sodium excretion, and serum calcium levels on the high calcium diet were not significantly different from those on the low calcium diet. In a second experiment, calcium was infused continuously for six days into the arterial circulation of normotensive or stress-salt hypertensive dogs at a rate of 0.12-0.23 mEq/min. Although serum calcium levels increased by up to 50% under these conditions, there were no significant effects on 24-hour levels of arterial pressure. In contrast to the protective effect of augmented potassium intake, these findings indicate that calcium intake does not influence the development of stress-salt hypertension in dogs.
在低钙（0.1%）或高钙（1.5%）饮食条件下，对犬进行12天的回避条件训练并给予等渗盐水（1.3升/天）。在低钙饮食（收缩压：+16±5毫米汞柱；舒张压：+6±2毫米汞柱）和高钙饮食（收缩压：+17±4毫米汞柱；舒张压：+11±4毫米汞柱）的应激-盐条件训练期间，24小时平均动脉压的升高幅度相当。高钙饮食组的尿量、钠排泄量和血清钙水平与低钙饮食组相比无显著差异。在第二个实验中，以0.12 - 0.23毫当量/分钟的速率向正常血压或应激-盐高血压犬的动脉循环中持续输注钙6天。尽管在这些条件下血清钙水平升高了50%，但对24小时动脉压水平没有显著影响。与增加钾摄入的保护作用相反，这些发现表明钙摄入不影响犬应激-盐高血压的发展。
