Martinier Isabelle, Trichet Léa, Fernandes Francisco M
Laboratoire de Chimie de la Matière Condensée de Paris, Sorbonne Université, UMR 7574, Paris 75005, France.
Chem Soc Rev. 2025 Jan 20;54(2):790-826. doi: 10.1039/d4cs00429a.
Repairing tubular tissues-the trachea, the esophagus, urinary and gastrointestinal tracts, and the circulatory system-from trauma or severe pathologies that require resection, calls for new, more effective graft materials. Currently, the relatively narrow family of materials available for these applications relies on synthetic polymers that fail to reproduce the biological and physical cues found in native tissues. Mimicking the structure and the composition of native tubular tissues to elaborate functional grafts is expected to outperform the materials currently in use, but remains one of the most challenging goals in the field of biomaterials. Despite their apparent diversity, tubular tissues share extensive compositional and structural features. Here, we assess the current state of the art through a dual layer model, reducing each tissue to an inner epithelial layer and an outer muscular layer. Based on this model, we examine the current strategies developed to mimic each layer and we underline how each fabrication method stands in providing a biomimetic material for future clinical translation. The analysis provided here, addressed to materials chemists, biomaterials engineers and clinical staff alike, sets new guidelines to foster the elaboration of new biomimetic materials for effective tubular tissue repair.
修复因创伤或严重病变而需要切除的管状组织（气管、食道、泌尿道和胃肠道以及循环系统），需要新型、更有效的移植材料。目前，用于这些应用的材料种类相对有限，主要依赖合成聚合物，而这些聚合物无法重现天然组织中的生物学和物理线索。模仿天然管状组织的结构和组成来制造功能性移植物有望优于目前使用的材料，但这仍然是生物材料领域最具挑战性的目标之一。尽管管状组织表面上具有多样性，但它们具有广泛的组成和结构特征。在这里，我们通过双层模型评估当前的技术水平，将每个组织简化为内层上皮层和外层肌肉层。基于此模型，我们研究了目前为模仿每层而开发的策略，并强调了每种制造方法在为未来临床转化提供仿生材料方面的优势。本文提供的分析面向材料化学家、生物材料工程师和临床工作人员，为促进开发用于有效管状组织修复的新型仿生材料制定了新的指导方针。
