喹诺酮类药物在治疗药物储备中的地位。

Place of quinolones in the therapeutic armoury.

作者信息

Van Klingeren B

出版信息

Pharm Weekbl Sci. 1986 Feb 21;8(1):40-1. doi: 10.1007/BF01975478.

DOI:10.1007/BF01975478

Abstract

On the basis of antimicrobial activity, resistance development, pharmacokinetics, side effects and pre-clinical results, the applicability of the quinolones ciprofloxacin, enoxacin, norfloxacin, ofloxacin and pefloxacin is assessed. These quinolones seem especially useful in infections in hospitalized patients, in gonococcal infections and in urinary tract infections. Also salmonellosis and shigellosis might be indications for quinolones.

摘要

基于抗菌活性、耐药性发展、药代动力学、副作用及临床前研究结果，对喹诺酮类药物环丙沙星、依诺沙星、诺氟沙星、氧氟沙星和培氟沙星的适用性进行了评估。这些喹诺酮类药物似乎对住院患者感染、淋球菌感染及尿路感染特别有用。沙门菌病和志贺菌病也可能是喹诺酮类药物的适应证。