Renaudin H, Quentin C, de Barbeyrac B, Bebear C
Laboratoire de Bactériologie, Hôpital Pellegrin, Bordeaux.
Pathol Biol (Paris). 1988 May;36(5):496-9.
The in vitro activity of new quinolones was evaluated against Mycoplasma pneumoniae (10 strains) and Mycoplasma hominis (approximately equal to 70 strains) by agar dilution, and against Ureaplasma urealyticum (approximately equal to 115 strains) by broth dilution. The static effect of pefloxacin, ofloxacin, ciprofloxacin, enoxacin was investigated for all the strains. Rosoxacin was included in the tests for U. urealyticum and M. hominis. Pefloxacin, ofloxacin, ciprofloxacin and enoxacin were within the same range of sensitivity for M. pneumoniae; the minimal inhibitory concentrations (MICs) of the 10 strains were 1 mg/l for ciprofloxacin, 2 mg/l for pefloxacin, MICs range was (0.05-1 mg/l) for ofloxacin and (0.5-4 mg/l) for enoxacin. Ciprofloxacin was the most active compound against M. hominis; MICs range and mode MICs were respectively in mg/l: (0.1-1) 0.5 for ciprofloxacin, (0.2-2) 0.5 for ofloxacin, (0.5-2) 1 for pefloxacin, (0.5-8) 2 for enoxacin, (2-16) 2 for rosoxacin. Ofloxacin was the most active compound against U. urealyticum; MICs range and mode MICs were respectively in mg/l: (0.2-2) 1 for ofloxacin, (0.1-8) 2 for rosoxacin, (0.5-8) 4 for pefloxacin, (1-16) 4 for ciprofloxacin, (2-32) 8 for enoxacin. No difference could be observed between tetracycline sensitive or resistant strains.
采用琼脂稀释法评估了新型喹诺酮类药物对肺炎支原体（10株）和人型支原体（约70株）的体外活性，采用肉汤稀释法评估了其对解脲脲原体（约115株）的体外活性。研究了培氟沙星、氧氟沙星、环丙沙星、依诺沙星对所有菌株的抑菌作用。在对解脲脲原体和人型支原体的测试中加入了罗索沙星。培氟沙星、氧氟沙星、环丙沙星和依诺沙星对肺炎支原体的敏感性范围相同；10株肺炎支原体的最低抑菌浓度（MIC）分别为：环丙沙星1mg/l，培氟沙星2mg/l，氧氟沙星的MIC范围为（0.05 - 1mg/l），依诺沙星为（0.5 - 4mg/l）。环丙沙星是人型支原体最有效的化合物；环丙沙星的MIC范围和MIC模式分别为mg/l：（0.1 - 1）0.5，氧氟沙星为（0.2 - 2）0.5，培氟沙星为（0.5 - 2）1，依诺沙星为（0.5 - 8）2，罗索沙星为（2 - 16）2。氧氟沙星是解脲脲原体最有效的化合物；氧氟沙星的MIC范围和MIC模式分别为mg/l：（0.2 - 2）1，罗索沙星为（0.1 - 8）2，培氟沙星为（0.5 - 8）4，环丙沙星为（1 - 16）4，依诺沙星为（2 - 32）8。四环素敏感或耐药菌株之间未观察到差异。
