需氧革兰氏阴性血培养分离株对恶喹酸、诺氟沙星、环丙沙星、依诺沙星、培氟沙星、氧氟沙星和氧恶喹酸的体外敏感性

In vitro susceptibility of aerobic gram-negative blood culture isolates to oxolinic acid, norfloxacin, ciprofloxacin, enoxacin, pefloxacin, ofloxacin and oxo-enoxacin.

作者信息

Van der Auwera P

出版信息

Infection. 1986 May-Jun;14(3):142-4. doi: 10.1007/BF01643481.

Abstract

100 gram-negative strains isolated from blood cultures were selected for the evaluation of the in vitro activity of oxolinic acid, norfloxacin, ciprofloxacin, enoxacin, pefloxacin, ofloxacin and oxo-enoxacin. Ciprofloxacin showed the highest intrinsic activity. Oxo-enoxacin, the major metabolite of enoxacin, was 10-15-fold less active than enoxacin. Against Enterobacteriaceae and Vibrionaceae, all fluorinated quinolones except norfloxacin were equally effective, while against non-fermenters, ciprofloxacin and ofloxacin demonstrated greater activity than the others. Resistance to oxolinic acid had a detrimental effect on susceptibility to the new fluorinated quinolones.

摘要

从血培养物中分离出100株革兰氏阴性菌株，用于评估恶喹酸、诺氟沙星、环丙沙星、依诺沙星、培氟沙星、氧氟沙星和氧代依诺沙星的体外活性。环丙沙星显示出最高的内在活性。依诺沙星的主要代谢产物氧代依诺沙星的活性比依诺沙星低10至15倍。在针对肠杆菌科和弧菌科方面，除诺氟沙星外的所有氟喹诺酮类药物效果相同，而在针对非发酵菌方面，环丙沙星和氧氟沙星显示出比其他药物更强的活性。对恶喹酸的耐药性对新型氟喹诺酮类药物的敏感性有不利影响。