Song Jiayi, Chang Weirong, Wang Yujie, Gao Peng, Zhang Jie, Xiao Zhipan, An Fangyu, Yan Chunlu
School of Basic Medicine, Gansu University of Chinese Medicine, Lanzhou, China.
School of Tradional Chinese and Werstern Medicine, Gansu University of Chinese Medicine, Lanzhou, China.
Biomol Biomed. 2025 Jan 30;25(3):511-524. doi: 10.17305/bb.2024.11200.
The Wnt signaling pathway is one of the most important and critical signaling pathways for maintaining cellular functions, such as cell proliferation and differentiation. Increasing evidence substantiates that the Wnt signaling pathway also plays a significant role in the regulation of bone formation in osteoporosis. Accordingly, inhibitors of this pathway, such as sclerostin, Dickkopf-1 (DKK1), WNT inhibitory factor 1 (WIF1), and secreted frizzled-related proteins (SFRPs), have a negative regulatory role in bone formation and may serve as effective therapeutic targets for osteoporosis. This review examines the mechanisms of action of Wnt signaling pathway inhibitors in osteoporosis, the relationship between the Wnt pathway and its inhibitors, and new molecular targets for osteoporosis treatment. Overall, the regulatory mechanisms of Wnt pathway inhibitors are summarized to provide scientific and theoretical guidance for the treatment and prevention of osteoporosis.
Wnt信号通路是维持细胞功能（如细胞增殖和分化）最重要和关键的信号通路之一。越来越多的证据证实，Wnt信号通路在骨质疏松症的骨形成调节中也起着重要作用。因此，该通路的抑制剂，如硬化蛋白、Dickkopf-1（DKK1）、WNT抑制因子1（WIF1）和分泌型卷曲相关蛋白（SFRP），在骨形成中具有负调节作用，可能成为骨质疏松症的有效治疗靶点。本文综述了Wnt信号通路抑制剂在骨质疏松症中的作用机制、Wnt通路与其抑制剂之间的关系以及骨质疏松症治疗的新分子靶点。总体而言，总结Wnt通路抑制剂的调节机制，为骨质疏松症的治疗和预防提供科学和理论指导。
