Tao Sha-Sha, Cao Fan, Sam Napoleon Bellua, Li Hong-Miao, Feng Ya-Ting, Ni Jing, Wang Peng, Li Xiao-Mei, Pan Hai-Feng
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China; Preventive Medicine Experimental Teaching Center, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, China; Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, Anhui, China.
Department of Ophthalmology, The Second Affiliated Hospital of Anhui Medical University, 678 Furong Road, Hefei, Anhui, China.
Clin Immunol. 2022 Dec;245:109156. doi: 10.1016/j.clim.2022.109156. Epub 2022 Oct 17.
Dickkopf-1 (DKK-1) is mostly known as a mature inhibitor of classic Wnt signaling pathways, which plays a critically role in regulating bone formation and bone metastasis. In recent years, the roles of DKK-1 played in bone resorption, bone formation, immune homeostasis and inflammation have been investigated. The role of DKK-1 in the pathogenesis and treatment of autoimmune diseases (ADs), including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), etc, has attracted widespread attention. Various studies have found that DKK-1 may be used as a biomarker for the occurrence and development of ADs, and as a potential target for the treatment of ADs. In this review, we have briefly summed up the intricate immunological functions and regulatory mechanisms of DKK-1 in ADs, aiming to further learning more about the role of DKK-1 involved in the pathogenesis of ADs and provide an outlook for the potential future researches.
Dickkopf-1（DKK-1）主要作为经典Wnt信号通路的成熟抑制剂为人所知，其在调节骨形成和骨转移中起关键作用。近年来，人们对DKK-1在骨吸收、骨形成、免疫稳态和炎症中的作用进行了研究。DKK-1在自身免疫性疾病（ADs），包括类风湿性关节炎（RA）、系统性红斑狼疮（SLE）等的发病机制和治疗中的作用已引起广泛关注。各种研究发现，DKK-1可用作ADs发生和发展的生物标志物，以及ADs治疗的潜在靶点。在这篇综述中，我们简要总结了DKK-1在ADs中的复杂免疫功能和调节机制，旨在进一步了解DKK-1在ADs发病机制中的作用，并为未来潜在的研究提供展望。
