Martin G E, Bacino C B, Papp N L
Peptides. 1980 Winter;1(4):333-9. doi: 10.1016/0196-9781(80)90011-x.
Changes in rectal temperature were measured after the intracerebral microinjection of neurotensin (2.5 micrograms/0.5 microliters) at 135 sites in the rat. At 63 of the 135 microinjection sites, the tridecapeptide produced a rapid onset of hypothermia ranging in magnitude from 0.8 to 2.3 degrees C below the baseline rectal temperature. The drop in rectal temperature persisted for 2-4 hours following the microinjection. The greatest concentrations of neurotensin-sensitive sites were found in the medial preoptic region of the hypothalamus and in the periaqueductal gray area, both of which contain relatively large amounts of endogenous neurotensin. Other active sites were found in the ventral thalamus, the dorsomedial hypothalamus, and in the diagonal band of Broca. At no injection site did neurotensin evoke an increase in rectal temperature. These data support the proposition that neurotensin may act endogenously to mediate heat-loss mechanisms in the rat. The data provide further evidence indicating a potent neuromodulatory role for neurotensin.
在大鼠脑内135个位点微量注射神经降压素（2.5微克/0.5微升）后，测量直肠温度的变化。在135个微量注射位点中的63个位点，该十三肽迅速引起体温过低，幅度在低于基线直肠温度0.8至2.3摄氏度之间。微量注射后，直肠温度下降持续2至4小时。在下丘脑视前内侧区和导水管周围灰质区域发现了对神经降压素敏感的位点的最高浓度，这两个区域都含有相对大量的内源性神经降压素。在腹侧丘脑、下丘脑背内侧和布罗卡斜带也发现了其他活跃位点。在任何注射位点，神经降压素均未引起直肠温度升高。这些数据支持了神经降压素可能在内源性地介导大鼠散热机制的观点。这些数据进一步证明了神经降压素具有强大的神经调节作用。
