Aqib Mohd, Khatoon Shahnaaz, Ali Mujahid, Sajid Shabana, Assiri Mohammed Ali, Ahamad Shakir, Saquib Mohammad, Hussain Mohd Kamil
Department of Chemistry, Govt. Raza P.G. College, Rampur, M. J. P. Rohilkhand University, Bareilly, UP, India.
Department of Botany, D.N. College Meerut, 250002, India.
Eur J Med Chem. 2025 Jan 15;282:117088. doi: 10.1016/j.ejmech.2024.117088. Epub 2024 Nov 22.
Natural coumarins and isocoumarins show significant therapeutic potential against cancer in preclinical studies by targeting multiple pathways and processes. These compounds influence several critical cellular processes, such as apoptosis, autophagy, and cell cycle regulation, which are pivotal in cancer development and progression. Their capability to target multiple signalling pathways provides a strategic advantage over single-target therapies, which are often limited by drug resistance. Notably, coumarins have the potential to inhibit angiogenesis, the process through which tumours develop new blood vessels, thereby potentially restricting tumour growth and metastasis. Additionally, coumarins may enhance anticancer effects by modulating immune responses and reducing inflammation, thus offering a dual approach to combating cancer. They also show promise in addressing multidrug resistance, a significant challenge in cancer therapy, by targeting drug efflux proteins and potentially improving the efficacy of existing treatments. While preclinical studies are promising, further research is required to elucidate the pharmacokinetics, toxicity, and potential side effects of coumarins in humans. Continued clinical evaluation will be crucial to confirm their effectiveness in cancer patients. Nonetheless, their ability to target multiple pathways positions coumarin based molecules as potential candidates for future anti-cancer drug development.
在临床前研究中，天然香豆素类和异香豆素类化合物通过靶向多种途径和过程，显示出显著的抗癌治疗潜力。这些化合物影响多个关键的细胞过程，如细胞凋亡、自噬和细胞周期调控，而这些过程在癌症的发生和发展中起着关键作用。它们靶向多种信号通路的能力相对于单靶点疗法具有战略优势，单靶点疗法往往受到耐药性的限制。值得注意的是，香豆素类化合物有可能抑制血管生成，即肿瘤形成新血管的过程，从而有可能限制肿瘤的生长和转移。此外，香豆素类化合物可能通过调节免疫反应和减轻炎症来增强抗癌效果，从而提供一种双重抗癌方法。它们在解决多药耐药性方面也显示出前景，多药耐药性是癌症治疗中的一个重大挑战，通过靶向药物外排蛋白并可能提高现有治疗方法的疗效来实现。虽然临床前研究很有前景，但还需要进一步研究来阐明香豆素类化合物在人体内的药代动力学、毒性和潜在副作用。持续的临床评估对于确认它们在癌症患者中的有效性至关重要。尽管如此，它们靶向多种途径的能力使基于香豆素的分子成为未来抗癌药物开发的潜在候选物。
