Zhang Wanying, Yuan Yuan, Pang Xiaoyan, Liu Yonghong, Zhang Xiaoyong, Liu Qingchao, Wang Junfeng
College of Chemical Engineering, Department of Pharmaceutical Engineering, Northwest University, Xi'an, 710069, China.
CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/Innovation Academy of South China Sea Ecology and Environmental Engineering, Chinese Academy of Sciences, South China Sea Institute of Oceanology, Guangzhou, 510301, P. R., China.
Chem Biodivers. 2024 Dec;21(12):e202401751. doi: 10.1002/cbdv.202401751. Epub 2024 Oct 18.
Four new compounds, including one drimane sesquiterpene lactone (1), one isocoumarin (2), one coumarin (3), and a new natural product (4), as well as fourteen known compounds were obtained from a deep-sea derived Cladosporium sp. SCSIO 41318. The structures of the new compounds were determined using extensive NMR and HRESIMS spectroscopic analysis, electronic circular dichroism calculations, and single-crystal X-ray diffraction measurements. Biological assays showed that compounds (1, 6, 7, 9-12, 14, 15, 17, 18) exhibited varying degrees of antimicrobial activity against the tested human pathogenic bacteria and plant pathogenic fungi. Besides, penicitrinone A (11) and penicitrinol A (12) displayed weak antitumor activities against the 22Rv1 cell line.
从一株深海来源的枝孢菌SCSIO 41318中获得了4个新化合物，包括1个杜松烷倍半萜内酯（1）、1个异香豆素（2）、1个香豆素（3）和1个新天然产物（4），以及14个已知化合物。通过广泛的核磁共振和高分辨电喷雾电离质谱光谱分析、电子圆二色性计算和单晶X射线衍射测量确定了新化合物的结构。生物活性测试表明，化合物（1、6、7、9 - 12、14、15、17、18）对测试的人类病原菌和植物病原菌表现出不同程度的抗菌活性。此外，青霉素酮A（11）和青霉素醇A（12）对22Rv1细胞系显示出较弱的抗肿瘤活性。
