Yi Jinfeng, Zhang Wanting, Li Yingpu, Ren He, Xiang Yuhang, Qiao Cong
Department of Pathology, Harbin Medical University, Harbin, Heilongjiang, China.
Department of Oncological Surgery, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang Province 150000, China; NHC Key Laboratory of Cell Transplantation, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province 150001, China.
Life Sci. 2025 Jan 1;360:123279. doi: 10.1016/j.lfs.2024.123279. Epub 2024 Nov 26.
Ferroptosis, a regulated form of cell death distinct from apoptosis and necrosis. Key hallmarks include iron-dependent lipid peroxidation, glutathione depletion, and intracellular iron accumulation, all of which are counteracted by specific cellular defenses. However, the immunosuppressive effects of ferroptosis induction in cancer immunotherapy remain unresolved. This review summarizes the recent advancements in ferroptosis research, focusing on its defensive mechanisms. It analyzes how ferroptosis affects both cancer and immune cells, highlighting its potential inhibitory effects on anti-tumor immunity and possible promotion of pro-tumor immune responses. Finally, this review briefly introduces case studies that combined ferroptosis induction with immunotherapy, offering novel perspectives for cancer treatment.
铁死亡是一种有别于凋亡和坏死的程序性细胞死亡形式。其关键特征包括铁依赖性脂质过氧化、谷胱甘肽耗竭和细胞内铁蓄积，所有这些均可被特定的细胞防御机制抵消。然而，在癌症免疫治疗中诱导铁死亡的免疫抑制作用仍未得到解决。本综述总结了铁死亡研究的最新进展，重点关注其防御机制。分析了铁死亡如何影响癌症细胞和免疫细胞，强调了其对抗肿瘤免疫的潜在抑制作用以及对促肿瘤免疫反应的可能促进作用。最后，本综述简要介绍了将诱导铁死亡与免疫治疗相结合的案例研究，为癌症治疗提供了新的视角。
