Wang Si-Jun, Wang Peng-Xin, Ding Hai-Ling, Qi Yuan-Yuan, Song Ya-Ru, Mu Xiao-Nan
School of Medicine, Qilu Institute of Technology, 3028 Jingshidong Road, Shandong, 250200, Jinan, China.
Department of Urology, Central Hospital Affiliated to Shandong First Medical University, Jinan, 250013, Shandong, China.
Discov Oncol. 2025 Jul 1;16(1):1207. doi: 10.1007/s12672-025-03052-7.
The search for effective and safe therapeutic options is the goal of clinical treatment for cancer patients. In recent years, natural products have received increasing attention in order to develop new drugs with good antitumor effects and fewer side effects. Arenobufagin (ARBU), an important active ingredient extracted from Toad venom, has been shown to exhibit anti-cancer effects in basic research. Studies have revealed that ARBU has a wide range of potent biological activities and plays an important role as an anti-tumor, anti-inflammatory, anti-oxidant, anti-viral, and for the treatment of cardiac insufficiency. ARBU has shown promising anti-cancer activity in preclinical research. Therefore, it has attracted increasing attention from researchers. In this paper, its antitumor effects were reviewed in terms of cell cycle arrest, induction of cell apoptosis and autophagy, improvement of immunity, inhibition of proliferation, angiogenesis, invasion and metastasis. In addition, the safety and toxicity of the compound were further discussed. Follow-up experiments, especially clinical trials, are needed in order to elucidate the benefits and adverse effects of ARBU on cancer patients.
寻找有效且安全的治疗方案是癌症患者临床治疗的目标。近年来，为了开发具有良好抗肿瘤效果且副作用较少的新药，天然产物受到了越来越多的关注。华蟾酥毒基（ARBU）是从蟾酥中提取的一种重要活性成分，在基础研究中已显示出抗癌作用。研究表明，ARBU具有广泛的强大生物活性，在抗肿瘤、抗炎、抗氧化、抗病毒以及治疗心功能不全方面发挥着重要作用。ARBU在临床前研究中已显示出有前景的抗癌活性。因此，它已引起研究人员越来越多的关注。本文从细胞周期阻滞、诱导细胞凋亡和自噬、提高免疫力、抑制增殖、血管生成、侵袭和转移等方面综述了其抗肿瘤作用。此外，还进一步讨论了该化合物的安全性和毒性。为了阐明ARBU对癌症患者的益处和不良反应，需要进行后续实验，尤其是临床试验。
