Wang Hongping, Tian Maoliang, Lai Qun, Li Wenqiang, Ding Hao, Deng Zhiping
Department of Neurosurgery, Zigong Fourth People's Hospital, 19 Tanmulin Street, Zigong, Sichuan 643000, China.
Department of Pulmonary and Critical Care Medicine, Zigong First People's Hospital, 42 Shangyihao Yizhi Street, Zigong, Sichuan 643000, China.
J Stroke Cerebrovasc Dis. 2025 Jan;34(1):108162. doi: 10.1016/j.jstrokecerebrovasdis.2024.108162. Epub 2024 Nov 27.
Stroke is the second leading cause of death worldwide. It remains unclear whether chronic obstructive pulmonary disease (COPD) increases the risk of stroke. The purpose of this study was to evaluate the association between COPD and stroke. As physical activity may prevent strokes, we examined whether leisure-time physical activity (LTPA) moderates stroke risk in COPD patients.
13,524 participants from the 2009-2018 National Health and Nutrition Examination Survey (NHANES). We used the Global Physical Activity Questionnaire (GPAQ) questionnaire to obtain self-reported data from LTPA. We used a binary logistic regression model to analyze the association between LTPA, COPD, and stroke risk.
The prevalence of COPD in the present study was 5.54%. The risk of stroke in COPD patients is 1.84 times higher than that in those without COPD, with a 95% confidence interval (95%CI) of 1.32,2.56 and P < 0.001. A lower stroke risk was observed in COPD patients who adhered to LTPA than those who did not (OR, 0.50; 95%CI, 0.26, 0.95; P = 0.03). As shown by the restricted cubic spline (RCS), the duration of LTPA in COPD patients was inversely related to the risk of stroke, which decreased as the duration of weekly LTPA increased.
COPD is positively associated with stroke risk. LTPA reduces the risk of stroke in patients with COPD, suggesting that it may be a promising measure for preventing stroke in this population.
中风是全球第二大致死原因。慢性阻塞性肺疾病（COPD）是否会增加中风风险仍不清楚。本研究的目的是评估COPD与中风之间的关联。由于体育活动可能预防中风，我们研究了休闲时间体育活动（LTPA）是否能降低COPD患者的中风风险。
来自2009 - 2018年国家健康与营养检查调查（NHANES）的13524名参与者。我们使用全球体育活动问卷（GPAQ）来获取LTPA的自我报告数据。我们使用二元逻辑回归模型来分析LTPA、COPD和中风风险之间的关联。
本研究中COPD的患病率为5.54%。COPD患者的中风风险比无COPD者高1.84倍，95%置信区间（95%CI）为1.32, 2.56，P < 0.001。坚持LTPA的COPD患者中风风险低于未坚持者（OR，0.50；95%CI，0.26，0.95；P = 0.03）。如受限立方样条（RCS）所示，COPD患者的LTPA时长与中风风险呈负相关，随着每周LTPA时长增加，中风风险降低。
COPD与中风风险呈正相关。LTPA可降低COPD患者的中风风险，表明它可能是预防该人群中风的一项有前景的措施。
