Xiang Na, Bai Jingshan, Li Wenqiang, Ge Yanlei, Deng Zhiping
Department of Clinical Medicine, North Sichuan Medical College, Nanchong 637000, Sichuan, China; Department of Pulmonary and Critical Care Medicine, Zigong First People's Hospital, Zigong 643000, Sichuan, China.
Department of Pulmonary and Critical Care Medicine, Xiong'an Xuanwu Hospital, Xiong'an New Area 070001, Hebei, China.
Heart Lung. 2025 Mar-Apr;70:263-270. doi: 10.1016/j.hrtlng.2025.01.004. Epub 2025 Jan 10.
Chronic inflammatory airway diseases (CIAD) are well-known risk factors for depression symptoms. There exists a complex interplay between leisure-time physical activity (LTPA) and depressive symptoms. However, the relationship between LTPA duration and depressive symptoms in CIAD patients remains unclear.
This study investigated NHANES data from 2007 to 2018 to investigate the relationship between LTPA and depressive symptoms in CIAD patients.
We collected data from National Health and Nutrition Examination Survey (NHANES) 2007-2018. Weighted logistic regression was employed to analyze the correlation between CIAD and depressive symptoms. Next, CIAD patients with LTPA information, the similar method was also employed to examine the association between LTPA and depressive symptoms. Finally, the dose-response relationship between LTPA duration and depressive symptoms was explored using restricted cubic spline (RCS) plot.
Consistent with previous research findings, patients with CIAD are more prone to experiencing symptoms of depression (P < 0.0001). Compared to CIAD patients without LTPA, patients who engage in LTPA have a lower probability of experiencing depressive symptoms (P < 0.0001). Interestingly, we had discovered that there is an l-shaped relationship between the duration of LTPA and the prevalence of depressive symptoms (non-linear P = 0.001). There is a threshold effect between the duration of LTPA and depressive symptoms. Within12 h/week, the risk of depressive symptoms in CIAD patients decreases with increased duration of LTPA. However, beyond 12 h/week, this association no longer exists.
Our research indicates that CIAD patients can increase the prevalence of depressive symptoms. And LTPA over a period of time is negatively correlated with depressive symptoms, but only up to a total duration of 12 h/week.
慢性炎症性气道疾病（CIAD）是抑郁症症状的众所周知的危险因素。休闲体育活动（LTPA）与抑郁症状之间存在复杂的相互作用。然而，CIAD患者中LTPA持续时间与抑郁症状之间的关系仍不清楚。
本研究调查了2007年至2018年的美国国家健康与营养检查调查（NHANES）数据，以研究CIAD患者中LTPA与抑郁症状之间的关系。
我们收集了2007 - 2018年美国国家健康与营养检查调查（NHANES）的数据。采用加权逻辑回归分析CIAD与抑郁症状之间的相关性。接下来，对于有LTPA信息的CIAD患者，也采用类似方法检查LTPA与抑郁症状之间的关联。最后，使用受限立方样条（RCS）图探索LTPA持续时间与抑郁症状之间的剂量反应关系。
与先前的研究结果一致，CIAD患者更容易出现抑郁症状（P < 0.0001）。与没有LTPA的CIAD患者相比，进行LTPA的患者出现抑郁症状的概率较低（P < 0.0001）。有趣的是，我们发现LTPA持续时间与抑郁症状患病率之间存在L形关系（非线性P = 0.001）。LTPA持续时间与抑郁症状之间存在阈值效应。在每周12小时以内，CIAD患者抑郁症状的风险随着LTPA持续时间的增加而降低。然而，超过每周12小时，这种关联不再存在。
我们的研究表明，CIAD患者会增加抑郁症状的患病率。并且一段时间内的LTPA与抑郁症状呈负相关，但仅在总持续时间达到每周12小时之前如此。
