Department of Infectious Diseases, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea.
J Vet Sci. 2024 Nov;25(6):e83. doi: 10.4142/jvs.24251.
One Health is a multisectoral cooperative and collaborative approach aimed at achieving integrated health by recognizing the interconnectedness of people, animals, plants, and the environment. In the modern world, the One Health approach is considered an essential perspective for overcoming various emerging diseases, including antimicrobial resistance (AMR). One of the top priority AMR infections is caused by carbapenem-resistant Enterobacterales (CRE), which are bacterial strains not susceptible to carbapenems, the last-resort antibiotics for clinical Gram-negative bacterial infections. Although carbapenems are not allowed to use in animals in the global community, various types of CRE are being reported among animals, including the carbapenemase-producing Enterobacterales (CPE). Therefore, since the dissemination and clinical infection of CPE represent a shared health threat, measures to raise awareness of this issue should be considered from the perspective of the One Health approach.
One Health 是一种多部门合作和协作的方法，旨在通过认识到人类、动物、植物和环境的相互联系来实现综合健康。在现代世界，One Health 方法被认为是克服各种新发疾病（包括抗菌素耐药性 (AMR)）的重要视角。AMR 感染的首要任务之一是由碳青霉烯类耐药肠杆菌科（CRE）引起的，这些细菌菌株对碳青霉烯类药物不敏感，碳青霉烯类药物是治疗革兰氏阴性菌临床感染的最后手段抗生素。尽管全球范围内不允许在动物中使用碳青霉烯类药物，但各种类型的 CRE 仍在动物中报告，包括产碳青霉烯酶肠杆菌科（CPE）。因此，由于 CPE 的传播和临床感染代表着共同的健康威胁，应从 One Health 方法的角度考虑提高对此问题认识的措施。
