新型武器炸药在植物中表现出持久毒性。

Oates Nicola C, Nay Edward R, Cary Timothy J, Rylott Elizabeth L, Bruce Neil C

Centre for Novel Agricultural Products, Department of Biology, University of York, York, UK.

Engineer Research and Development Center, Cold Regions Research and Engineering Laboratory, Biogeochemical Sciences Branch, US Army Corps of Engineers, Hanover, NH, USA.

Nat Plants. 2025 Jan;11(1):16-22. doi: 10.1038/s41477-024-01863-0. Epub 2024 Nov 28.

Explosives are widespread, toxic and persistent environmental pollutants. 2,4-Dinitroanisole (DNAN) is being phased in to replace 2,4,6-trinitrotoluene (TNT) in munitions. Here we demonstrate that only low levels of DNAN are detoxified in Arabidopsis, leaving it to remain as a substrate for monodehydroascorbate reductase 6 mediated chronic phytotoxicity. Enhancing the potential for environmental toxicity, DNAN is readily transported to the aerial tissues exposing this toxin to herbivores and the wider food chain.

爆炸物是广泛存在、有毒且持久的环境污染物。2,4-二硝基苯甲醚（DNAN）正在逐步被用于取代弹药中的2,4,6-三硝基甲苯（TNT）。在此我们证明，在拟南芥中只有低水平的DNAN被解毒，使其仍作为单脱氢抗坏血酸还原酶6介导的慢性植物毒性的底物。DNAN易于转运到地上组织，使这种毒素暴露于食草动物和更广泛的食物链中，从而增强了环境毒性。