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新型武器炸药在植物中表现出持久毒性。

New weapons explosive exhibits persistent toxicity in plants.

作者信息

Oates Nicola C, Nay Edward R, Cary Timothy J, Rylott Elizabeth L, Bruce Neil C

机构信息

Centre for Novel Agricultural Products, Department of Biology, University of York, York, UK.

Engineer Research and Development Center, Cold Regions Research and Engineering Laboratory, Biogeochemical Sciences Branch, US Army Corps of Engineers, Hanover, NH, USA.

出版信息

Nat Plants. 2025 Jan;11(1):16-22. doi: 10.1038/s41477-024-01863-0. Epub 2024 Nov 28.

DOI:10.1038/s41477-024-01863-0
PMID:39609535
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11757145/
Abstract

Explosives are widespread, toxic and persistent environmental pollutants. 2,4-Dinitroanisole (DNAN) is being phased in to replace 2,4,6-trinitrotoluene (TNT) in munitions. Here we demonstrate that only low levels of DNAN are detoxified in Arabidopsis, leaving it to remain as a substrate for monodehydroascorbate reductase 6 mediated chronic phytotoxicity. Enhancing the potential for environmental toxicity, DNAN is readily transported to the aerial tissues exposing this toxin to herbivores and the wider food chain.

摘要

爆炸物是广泛存在、有毒且持久的环境污染物。2,4-二硝基苯甲醚（DNAN）正在逐步被用于取代弹药中的2,4,6-三硝基甲苯（TNT）。在此我们证明，在拟南芥中只有低水平的DNAN被解毒，使其仍作为单脱氢抗坏血酸还原酶6介导的慢性植物毒性的底物。DNAN易于转运到地上组织，使这种毒素暴露于食草动物和更广泛的食物链中，从而增强了环境毒性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1964/11757145/d268fcf60993/41477_2024_1863_Fig7_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1964/11757145/eaaa7516e483/41477_2024_1863_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1964/11757145/460c0cabc1d7/41477_2024_1863_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1964/11757145/35f0b7857262/41477_2024_1863_Fig3_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1964/11757145/7a7861e8b7d8/41477_2024_1863_Fig4_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1964/11757145/a230c1f72ecf/41477_2024_1863_Fig5_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1964/11757145/80da7d7a738a/41477_2024_1863_Fig6_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1964/11757145/d268fcf60993/41477_2024_1863_Fig7_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1964/11757145/eaaa7516e483/41477_2024_1863_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1964/11757145/460c0cabc1d7/41477_2024_1863_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1964/11757145/35f0b7857262/41477_2024_1863_Fig3_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1964/11757145/7a7861e8b7d8/41477_2024_1863_Fig4_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1964/11757145/a230c1f72ecf/41477_2024_1863_Fig5_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1964/11757145/80da7d7a738a/41477_2024_1863_Fig6_ESM.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1964/11757145/d268fcf60993/41477_2024_1863_Fig7_ESM.jpg

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本文引用的文献

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Redox Biol. 2024 Jun;72:103082. doi: 10.1016/j.redox.2024.103082. Epub 2024 Feb 15.
2
Right on target: using plants and microbes to remediate explosives.精准施策：利用植物和微生物来修复爆炸物。
Int J Phytoremediation. 2019;21(11):1051-1064. doi: 10.1080/15226514.2019.1606783. Epub 2019 May 6.
3
Glutathione S-Transferases: Role in Combating Abiotic Stresses Including Arsenic Detoxification in Plants.
谷胱甘肽 S-转移酶：在植物对抗非生物胁迫（包括砷解毒）中的作用
Front Plant Sci. 2018 Jun 7;9:751. doi: 10.3389/fpls.2018.00751. eCollection 2018.
4
Metabolism and Photolysis of 2,4-Dinitroanisole in Arabidopsis.2,4-二硝基苯甲醚在拟南芥中的代谢和光解。
Environ Sci Technol. 2017 Dec 5;51(23):13714-13722. doi: 10.1021/acs.est.7b04220. Epub 2017 Nov 13.
5
Batch soil adsorption and column transport studies of 2,4-dinitroanisole (DNAN) in soils.土壤中2,4-二硝基苯甲醚（DNAN）的批量土壤吸附和柱传输研究。
J Contam Hydrol. 2017 Apr;199:14-23. doi: 10.1016/j.jconhyd.2017.02.004. Epub 2017 Mar 1.
6
Expression of a Drosophila glutathione transferase in Arabidopsis confers the ability to detoxify the environmental pollutant, and explosive, 2,4,6-trinitrotoluene.在拟南芥中表达果蝇谷胱甘肽转移酶赋予其解毒环境污染物，即爆炸物 2,4,6-三硝基甲苯的能力。
New Phytol. 2017 Apr;214(1):294-303. doi: 10.1111/nph.14326. Epub 2016 Dec 6.
7
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